Anemia

Question 1

Which cells indicate lead poisoning?

Answer 1

Basophillic Stippling

Question 2

Poikolocytosis

Answer 2

Change is red blood cell shape

Question 3

polychromasia

Answer 3

The presence of immature RBC’s in the smear.

Elevated reticulocytes

Question 4

Nucleated RBC’s

Answer 4

Indicated serious stress on the bone marrow.
Severe bleeding, severe hemolysis
Ominous sign

Question 5

Hypersegmented neutrophils indicate?

Answer 5

B12 or Folate deficiency

Question 6

Spherocytes

Answer 6

hereditary spherocytosis and

autoimmune hemolytic anemia

Question 7

Low ferritin level indicates?

Answer 7

Iron deficiency anemia. gold standard

NO iron stores are left

Question 8

Male hgb range

Answer 8

13.5 - 16.5

Question 9

Female hgb range

Answer 9

12.0 - 15.0

Question 10

Male hematocrit range

Answer 10

41 - 50

Question 11

Female hematocrit range

Answer 11

36 - 44

Question 12

Normal RDW

Answer 12

Less than 14.5

Question 13

MCV range

Answer 13

80 - 100

Question 14

MCH range

Answer 14

26 - 34

Question 15

Platelet range

Answer 15

100,000 - 450,000

Question 16

cobalmin

Answer 16

B12

Question 17

Anisocytosis

Answer 17

Change in size of RBC’s

Question 18

Cooley’s Anemia

Answer 18

Beta Thalassemia Major

Question 19

G6PD

Answer 19

Closely linked to Favism

Helps protect red blood cells from oxidative damage.

Question 20

G6PD deficiency

Answer 20

Non-immune X-linked hereditary disease that causes hemolysis of the RBC

Question 21

That triggers a G6PD associated hemolytic attack?

Answer 21

Fava Beans, Infection, certain meds.

Question 22

G5PD deficiency only manifests itself in _______.

Answer 22

Males, because it is X-linked.

Most common in african, middle eastern and south asian.

Question 23

Which type of Pica is pathognomonic for iron deficiency?

Answer 23

Pagophagia: eating ice.

Question 24

Both methylmalonic acid and Homocysteine are elevated in?

Answer 24

B12 deficiency

Question 25

Most common cause of folate deficiency?

Answer 25

Poor diet and alcoholism

Question 26

Liver disease leads to?

Answer 26

Macrocytosis and target cells

Question 27

Treatment of chronic renal failure anemia?

Answer 27

EPO (procrit, epoetin)

Question 28

Normal retic count?

Answer 28

1 - 2%

Question 29

Is intravascular or extravascular hemolytic anemia more common?

Answer 29

Extravascular, meaning it occurs in the spleen, liver and marrow

Question 30

What does a positive coombs test indicate?

Answer 30

It is an immune-mediated hemolytic anemia

Question 31

Microangiopathic hemolytic anemia

Answer 31

Occurs when vasculature is partially occluded by fibrin

Question 32

What do schistocytes indicate?

Answer 32

These are also called helmet cells. INdicate a microangiopathic anemia Most common is aortic stenosis

Question 33

Warm autoimmune hemolytic anemia

Answer 33

Peripheral smear shows polychromasia and spherocytes

Question 34

Harrison's disease

Answer 34

Heriditary hemochromatosis caused by excessive intestinal absorption Most commonly found in whites

Question 35

What is the first organ affected in iron overload?

Answer 35

The liver.

Question 36

What does a transferrin saturation of over 50% indicate?

Answer 36

Iron overload. | An elevated ferritin will also be seen.

Question 37

What is the treatment for harrison's disease?

Answer 37

Phlebotomy

Question 38

Recommended dose of ELEMENTAL iron/day?

Answer 38

150 - 200 mg

Question 39

Should iron dextran be given IM?

Answer 39

No, it is painful and should be given IV.

Question 40

If asthma or RA is present, Iron dextran is premedicated with?

Answer 40

125 mg of methylpred then | 1mg/kg/day x 4 for RA.

Question 41

Iron dextran dosage?

Answer 41

1,000 mg can be given at a time over 1 - 6 hours. Dilute in 250 to 1L of NS.

Question 42

which hormone inactivates ferroportin?

Answer 42

Hepcidin

Question 43

Which chain is affected in sickle cell anemia?

Answer 43

The beta chain

Question 44

What should be avoided in a child's diet?

Answer 44

Cows milk, it competes with iron and decreases the absorption.

Question 45

What is considered anemic for a pregnant women

Answer 45

Less than 11

Question 46

Suggested iron intake for pregnancy

Answer 46

30mg/day

Question 47

To prevent neural tube defects, the women should take folate _______?

Answer 47

Prior to conception and during pregnancy. Build up stores | 0.4 mg/day

Question 48

90% of alcoholics have ________.

Answer 48

Macrocytosis