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Flashcards in Anemia Deck (48):
1

Which cells indicate lead poisoning?

Basophillic Stippling

2

Poikolocytosis

Change is red blood cell shape

3

polychromasia

The presence of immature RBC's in the smear.
Elevated reticulocytes

4

Nucleated RBC's

Indicated serious stress on the bone marrow.
Severe bleeding, severe hemolysis
Ominous sign

5

Hypersegmented neutrophils indicate?

B12 or Folate deficiency

6

Spherocytes

hereditary spherocytosis and
autoimmune hemolytic anemia

7

Low ferritin level indicates?

Iron deficiency anemia. gold standard
NO iron stores are left

8

Male hgb range

13.5 - 16.5

9

Female hgb range

12.0 - 15.0

10

Male hematocrit range

41 - 50

11

Female hematocrit range

36 - 44

12

Normal RDW

Less than 14.5

13

MCV range

80 - 100

14

MCH range

26 - 34

15

Platelet range

100,000 - 450,000

16

cobalmin

B12

17

Anisocytosis

Change in size of RBC's

18

Cooley's Anemia

Beta Thalassemia Major

19

G6PD

Closely linked to Favism
Helps protect red blood cells from oxidative damage.

20

G6PD deficiency

Non-immune X-linked hereditary disease that causes hemolysis of the RBC

21

That triggers a G6PD associated hemolytic attack?

Fava Beans, Infection, certain meds.

22

G5PD deficiency only manifests itself in _______.

Males, because it is X-linked.
Most common in african, middle eastern and south asian.

23

Which type of Pica is pathognomonic for iron deficiency?

Pagophagia: eating ice.

24

Both methylmalonic acid and Homocysteine are elevated in?

B12 deficiency

25

Most common cause of folate deficiency?

Poor diet and alcoholism

26

Liver disease leads to?

Macrocytosis and target cells

27

Treatment of chronic renal failure anemia?

EPO (procrit, epoetin)

28

Normal retic count?

1 - 2%

29

Is intravascular or extravascular hemolytic anemia more common?

Extravascular, meaning it occurs in the spleen, liver and marrow

30

What does a positive coombs test indicate?

It is an immune-mediated hemolytic anemia

31

Microangiopathic hemolytic anemia

Occurs when vasculature is partially occluded by fibrin

32

What do schistocytes indicate?

These are also called helmet cells.
INdicate a microangiopathic anemia
Most common is aortic stenosis

33

Warm autoimmune hemolytic anemia

Peripheral smear shows polychromasia and spherocytes

34

Harrison's disease

Heriditary hemochromatosis caused by excessive intestinal absorption
Most commonly found in whites

35

What is the first organ affected in iron overload?

The liver.

36

What does a transferrin saturation of over 50% indicate?

Iron overload.
An elevated ferritin will also be seen.

37

What is the treatment for harrison's disease?

Phlebotomy

38

Recommended dose of ELEMENTAL iron/day?

150 - 200 mg

39

Should iron dextran be given IM?

No, it is painful and should be given IV.

40

If asthma or RA is present, Iron dextran is premedicated with?

125 mg of methylpred then
1mg/kg/day x 4 for RA.

41

Iron dextran dosage?

1,000 mg can be given at a time over 1 - 6 hours. Dilute in 250 to 1L of NS.

42

which hormone inactivates ferroportin?

Hepcidin

43

Which chain is affected in sickle cell anemia?

The beta chain

44

What should be avoided in a child's diet?

Cows milk, it competes with iron and decreases the absorption.

45

What is considered anemic for a pregnant women

Less than 11

46

Suggested iron intake for pregnancy

30mg/day

47

To prevent neural tube defects, the women should take folate _______?

Prior to conception and during pregnancy. Build up stores
0.4 mg/day

48

90% of alcoholics have ________.

Macrocytosis