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Flashcards in Onc Deck (53):
1

Ph Chromosome =

CML
also Bcr-Abl mutation

2

Which med treats CML?

Gleevec
Decreases risk for crisis de la blasts

3

African americans and pacific islanders are at higher risk for which blood dz?

MM

4

Monoclonal protein, roleaux formation =

MM

5

Most common adult leukemia?

CLL
affects B lymphocytes

6

smudge cells =

CLL

7

Which blood dz is hydroxyurea and asa used to tx?

PV

8

Cisplatin causes?

Renal tox

9

Which med causes ruby red urine?

Adriamycin

10

Which drug treats B-cell NHL

Rituximab
Cardiotoxic

11

Ipilimubab causes?

Endocrine failure
No cortisol

12

Cytoxan (cyclophosphamide) causes?

Hemorrhagic cystitis

13

Vincristine causes?

Peripheral Neuropathy

14

Does DCIS affect one or 2 breasts?

Always one

15

Infiltrating ductal carcinoma

Most common type of invasive BCA

16

Which therapy is used for ER/PR tumors?

Tamoxifen

17

What is used for HER2 BCA?

Trastazumab

18

Doxyrubicin causes?

Cardiac complications

19

Bleomycin causes?

Pulmonary fibrosis

20

What is a SE of tamoxifen

blood clots

21

Which ovarian CA occurs in younger women?

Germ Cell

22

What is the most common ovarian CA in older women?

Epithelial

23

Tests for ovarian CA

CA-125 and HE4

24

BRCA genes are associated with which cancers?

Breast and Ovarian

25

Is radiation used for ovarian CA?

No

26

Most common GYN CA in the US?

Endometrial

27

Type 1 Adenocarcinoma

Estrogen sensitive Endometrial CA
Good prognosis
Most common

28

Progestin

If added to hormone replacement therapy, lowers risk of endometrial CA.

29

HNPCC

Hereditary non-polyposis Colorectal cancer
Lynch syndrome
Runs in families

30

Squamous cell cervical CA

Most common type

31

What causes cervical CA?

HPV 16, 18, 45

32

Which blood dz usually causes leukostasis?

AML

33

Breast and lung cancer can release which hormone?

PTHrP
Hypercalcemia ensues

34

Small cell lung cancer secretes?

SIADH

35

Hypotension
JVD
Muffled heart sounds

Becks triad of cardiac tamponade

36

A smoker with hyponatremia

SIADH from SCLC

37

What kind of bone lesions does breast CA make?

Lytic bone lesions

38

Ewing lesions are lytic or blastic?

lytic then blastic

39

Benign lesions of skeletal long bones. Knee and shoulder are common. Most common skeletal neoplasms.

Osteochondroma

40

What type of bone lesions does prostate CA make?

Osteoblastic

41

Most common primary bone tumor?

MM

42

Which sites met to bone?

Breast
Prostate
Lung
Kidney
Thyroid

43

Most common bone malignancy in kids

Osteosarcoma
Long bones
Males in 2nd decade

44

Lytic lesion of the pelvis or long bones with onion skin and blue cells?

Ewing sarcoma

45

Axial skeleton tumors in adults that are slow growing and metastasize to lungs?

Chondrosarcoma
Also have stippled calcification

46

AFP detects?

Liver and germ cell CA

47

Beta hCG detects?

Choriocarcinoma and Testicular CA

48

CA 19.9

Pancreatic, bile duct, gall bladder, gastric CA

49

CA 125

Ovarian CA

50

CEA

Colorectal and Breast CA

51

Calcitonin

Medullary thyroid CA

52

Reed sternberg cell =?

Hodgkin Lymphoma

53

Sunburst pattern, codman's triangle

Osteosarcoma