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Flashcards in Week 2 Deck (57):
1

Which factors are vitamin K dependent?

II, VII, IX and X, C and S

2

Intrinsic pathway

9 - 12

3

Extrinsic Pathway

Tissue factor and factor VII.

4

Common meeting point for pathways?

X

5

Warfarin Inhibits....

Vitamin K dependent factors (2,7,9,10,)

6

tPA inhibits?

Plasminogen to plasmin

7

Heparin inhibits?

Xa and IIa (thrombin)

8

Antithrombin acts on?

X and thrombin

9

Protein C acts on?

VIIIa and Va

10

Prothrombin Time (PT) Measures?

Extrinsic pathway (VII), and warfarin.

11

PTT Measures?

Both pathways, and heparin.

12

Acquired protein C deficiency

Is caused by warfarin. This leads to warfarin-induced protein C deficiency, and skin necrosis.

13

Bridging

Heparin should be bridged with warfarin during the initial days of therapy to avoid skin necrosis.

14

Protamine sulfate

Reverses Heparin

15

What is amicar?

An antifibrinolytic agent. AKA ECA (aminocaproid acid)
Used for acute bleeding

16

What can reverse bleeding in a pt on pradaxa?

Autoplex T

17

What factors does DDAVP promote?

vWF and VIII

18

What is used during percutaneous cardiac intervention?

GPIIb/IIIa inhibitors

19

What is used as a hemostatic agent during CABG surgery?

Aprotinin

20

Which disease do you see a rouleaux formation in?

MM, you will also see fractures

21

What does CRAB stand for?

Calcium (elevated)
Renal failure
Anemia
Bone lesions
indicative of MM

22

What drug will help in spinal cord compression from MM?

Corticosteroids (SWELLING!)

23

Which serum antibody will you see elevated in Waldenstroms Macroglobulinemia (WM)

IgM

24

Having MM puts you at risk for?

Amyloidosis, the deposit of antibodies in organs and joints causing pathology.

25

Cast neuropathy is seen in?

MM

26

A plasmacytoma can progress to?

MM

27

Which age group is MM seen in?

65 and older

28

If you see marked leukocytosis and Auer rods, what would you suspect?

Acule Myeloid Leukemia

29

What is gout common in?

Myeloid leukemias

30

What is lymphadenopathy common in?

Lymphocytic Leukemias

31

A child presenting with leukocytosis and bone pain , organomegaly and lymphadenopathy most likely has?

Acute lymphocytic leukemia

32

Which leukemia is the philadelphia chromosome associated with?

Chronic Myeloid Leukemia

33

If you see leukemia cutis, soccer balls and smudge cells, what would you suspect?

Chronic Lymphocytic Leukemia

34

In which disorder is the bone marrow replaced with fibrous connective tissue?

Primary Myelofibrosis

35

If a patient complains of pruritis post-showering, and burning in the hands an feet, what would you suspect?

Polycythemia Vera

36

In which leukemia would you expect to see normal Hct and Platelets?

CLL

37

A presence of CD20 and absence of CD56 indicates that It is MM or PML?

It indicates Plasma Cell Leukemia

38

A markedly elevated platelet count and history of thrombosis indicates?

Essential Thrombocytosis

39

What would you suspect with a normo/normo anemia, Normal WBC count, 0% Retic, and no RBC precursors in the BM?

Pure Red Cell Aplasia

40

When the BM is "displaced" into other tissues and many immature, nucleated RBC's, Dacrocytes (tear-drop), and Blasts are seen in the periphery, what do you suspect?

Myelophthisic Anemia

41

Neoplasm =

Tumor

42

"Pre-leukemia"

Myelodysplastic Syndrome

43

An acutely ill patient presents with severe anemia, pancytopenia, NO spleno or hepatomegaly. What do you suspect?

Aplastic Anemia

44

What is the most common etiology of inherited BM failure? MCC and DEB fragility tests are used to Dx.

Fanconi's Anemia.
Developmental abnormalities are also common in this disorder.

45

Platelets being marked by antibodies and being destroyed by the spleen indicate?

ITP

46

Occurs after infection in children and is fleeting. Is often chronic in adults. Purpura.

ITP

47

Microangiopathic hemolytic anemia, with schistocytes, bleeding and clotting, Elevated liver enzymes, Clots in brain and kidneys, death.

TTP

48

Caused by endothelial damage secondary to infxn (E. coli most common). Bloody diarrhea.

HUS

49

A child with IgA Vasculitis, palpable purpura, arthralgias.

Henoch-Schonelin Purpura HSP

50

A man with bleeding in joints and a hx of bleeding after surgeries and tooth extractions, Prolonged PTT.

Hemophilia

51

A women with prolonged bleeding, easy bruising, bleeding from gums. She needed a transfusion post-delivery 2 years ago.

vWD

52

A septic patient who is now simultaneously bleeding and clotting. Every lab is prolonged and he is dying.

DIC

53

in vWD, what can you treat bleeding with?

DDAVP

54

What should you give to treat gout?

Allopurinol

55

How is erythromelalgia best treated, and which disease do you see it in?

Aspirin, Polycythemia Vera

56

Hydroxyurea and Alpha interferon are?

Myelosuppressive agents

57

What is ADAMTS associated with?

TTP