Week 2

Question 1

Which factors are vitamin K dependent?

Answer 1

II, VII, IX and X, C and S

Question 2

Intrinsic pathway

Answer 2

9 - 12

Question 3

Extrinsic Pathway

Answer 3

Tissue factor and factor VII.

Question 4

Common meeting point for pathways?

Answer 4

X

Question 5

Warfarin Inhibits….

Answer 5

Vitamin K dependent factors (2,7,9,10,)

Question 6

tPA inhibits?

Answer 6

Plasminogen to plasmin

Question 7

Heparin inhibits?

Answer 7

Xa and IIa (thrombin)

Question 8

Antithrombin acts on?

Answer 8

X and thrombin

Question 9

Protein C acts on?

Answer 9

VIIIa and Va

Question 10

Prothrombin Time (PT) Measures?

Answer 10

Extrinsic pathway (VII), and warfarin.

Question 11

PTT Measures?

Answer 11

Both pathways, and heparin.

Question 12

Acquired protein C deficiency

Answer 12

Is caused by warfarin. This leads to warfarin-induced protein C deficiency, and skin necrosis.

Question 13

Bridging

Answer 13

Heparin should be bridged with warfarin during the initial days of therapy to avoid skin necrosis.

Question 14

Protamine sulfate

Answer 14

Reverses Heparin

Question 15

What is amicar?

Answer 15

An antifibrinolytic agent. AKA ECA (aminocaproid acid)

Used for acute bleeding

Question 16

What can reverse bleeding in a pt on pradaxa?

Answer 16

Autoplex T

Question 17

What factors does DDAVP promote?

Answer 17

vWF and VIII

Question 18

What is used during percutaneous cardiac intervention?

Answer 18

GPIIb/IIIa inhibitors

Question 19

What is used as a hemostatic agent during CABG surgery?

Answer 19

Aprotinin

Question 20

Which disease do you see a rouleaux formation in?

Answer 20

MM, you will also see fractures

Question 21

What does CRAB stand for?

Answer 21

Calcium (elevated)
Renal failure
Anemia
Bone lesions
indicative of MM

Question 22

What drug will help in spinal cord compression from MM?

Answer 22

Corticosteroids (SWELLING!)

Question 23

Which serum antibody will you see elevated in Waldenstroms Macroglobulinemia (WM)

Answer 23

IgM

Question 24

Having MM puts you at risk for?

Answer 24

Amyloidosis, the deposit of antibodies in organs and joints causing pathology.

Question 25

Cast neuropathy is seen in?

Answer 25

MM

Question 26

A plasmacytoma can progress to?

Answer 26

MM

Question 27

Which age group is MM seen in?

Answer 27

65 and older

Question 28

If you see marked leukocytosis and Auer rods, what would you suspect?

Answer 28

Acule Myeloid Leukemia

Question 29

What is gout common in?

Answer 29

Myeloid leukemias

Question 30

What is lymphadenopathy common in?

Answer 30

Lymphocytic Leukemias

Question 31

A child presenting with leukocytosis and bone pain , organomegaly and lymphadenopathy most likely has?

Answer 31

Acute lymphocytic leukemia

Question 32

Which leukemia is the philadelphia chromosome associated with?

Answer 32

Chronic Myeloid Leukemia

Question 33

If you see leukemia cutis, soccer balls and smudge cells, what would you suspect?

Answer 33

Chronic Lymphocytic Leukemia

Question 34

In which disorder is the bone marrow replaced with fibrous connective tissue?

Answer 34

Primary Myelofibrosis

Question 35

If a patient complains of pruritis post-showering, and burning in the hands an feet, what would you suspect?

Answer 35

Polycythemia Vera

Question 36

In which leukemia would you expect to see normal Hct and Platelets?

Answer 36

CLL

Question 37

A presence of CD20 and absence of CD56 indicates that It is MM or PML?

Answer 37

It indicates Plasma Cell Leukemia

Question 38

A markedly elevated platelet count and history of thrombosis indicates?

Answer 38

Essential Thrombocytosis

Question 39

What would you suspect with a normo/normo anemia, Normal WBC count, 0% Retic, and no RBC precursors in the BM?

Answer 39

Pure Red Cell Aplasia

Question 40

When the BM is "displaced" into other tissues and many immature, nucleated RBC's, Dacrocytes (tear-drop), and Blasts are seen in the periphery, what do you suspect?

Answer 40

Myelophthisic Anemia

Question 41

Neoplasm =

Answer 41

Tumor

Question 42

"Pre-leukemia"

Answer 42

Myelodysplastic Syndrome

Question 43

An acutely ill patient presents with severe anemia, pancytopenia, NO spleno or hepatomegaly. What do you suspect?

Answer 43

Aplastic Anemia

Question 44

What is the most common etiology of inherited BM failure? MCC and DEB fragility tests are used to Dx.

Answer 44

Fanconi's Anemia. | Developmental abnormalities are also common in this disorder.

Question 45

Platelets being marked by antibodies and being destroyed by the spleen indicate?

Answer 45

ITP

Question 46

Occurs after infection in children and is fleeting. Is often chronic in adults. Purpura.

Answer 46

ITP

Question 47

Microangiopathic hemolytic anemia, with schistocytes, bleeding and clotting, Elevated liver enzymes, Clots in brain and kidneys, death.

Answer 47

TTP

Question 48

Caused by endothelial damage secondary to infxn (E. coli most common). Bloody diarrhea.

Answer 48

HUS

Question 49

A child with IgA Vasculitis, palpable purpura, arthralgias.

Answer 49

Henoch-Schonelin Purpura HSP

Question 50

A man with bleeding in joints and a hx of bleeding after surgeries and tooth extractions, Prolonged PTT.

Answer 50

Hemophilia

Question 51

A women with prolonged bleeding, easy bruising, bleeding from gums. She needed a transfusion post-delivery 2 years ago.

Answer 51

vWD

Question 52

A septic patient who is now simultaneously bleeding and clotting. Every lab is prolonged and he is dying.

Answer 52

DIC

Question 53

in vWD, what can you treat bleeding with?

Answer 53

DDAVP

Question 54

What should you give to treat gout?

Answer 54

Allopurinol

Question 55

How is erythromelalgia best treated, and which disease do you see it in?

Answer 55

Aspirin, Polycythemia Vera

Question 56

Hydroxyurea and Alpha interferon are?

Answer 56

Myelosuppressive agents

Question 57

What is ADAMTS associated with?

Answer 57

TTP