Anemia 2 Flashcards
(24 cards)
Is size usually helpful when diagnosing non-regenerative anemia?
What is an exception to this?
- No
- FeLV induced macrocytosis
Defective or decreased RBC production can be a result of what?
Non-responsive bone marrow
Is RBC morphology usually helpful when diagnosing non-regenerative anemia?
No
Can a biochemical profile be helpful in diagnosing non-regenerative anemia?
What is an example?
- Yes
- Anemia of renal disease
Can a bone marrow aspirate be helpful in diagnosing non-regenerative anemia?
Yes
What is the term for decreased red cell production?
Hypoplasia
What is the term used for complete lack of red blood cell production?
Aplasia
With a generalized anemia due to bone marrow problems, what can be seen?
All cell lines are decreased.
What is another term for general marrow suppression?
Aplastic anemia
What are 3 possible causes of aplastic anemia?
- Infectious agents (Ehrlichia, FeLV)
- Immune-mediated destruction
- Drugs and chemicals
What are 2 examples of types of drugs that can cause aplastic anemia?
- Antineoplastic
- Immunosuppressive drugs
What is an example of a toxin that can cause aplastic anemia?
Solvents such as benzene.
Estrogen can cause aplastic anemia in what 2 species?
- Dogs
- Ferrets
What are 4 conditions that can contribute to estrogen causing aplastic anemia?
- Iatrogenic
- Granulosa cell tumors
- Sertoli cell tumors
- Unspayed female ferrets
The mechanism thought to cause estrogen related aplastic anemia is mediated through what organ?
The thymus
Bone marrow suppression is preceded by what with aplastic anemia?
Initial thrombocytosis and neutrophilia
What are 3 examples of infectious agents that can cause aplastic anemia?
- FeLV
- Ehrlichia
- EIA (lentivirus)
Antibodies are directed against stem cells in what type of anemia?
Immune-mediated aplastic anemia
What are 3 examples of drugs that can induce immune-mediated aplastic anemia?
- Trimethoprim-sulfadiazine
- Cephalosporin
- Phenobarbital in dogs
Can immune-mediated aplastic anemia be idiopathic?
Yes
Is “pure red cell aplasia” common or rare?
Rare
What are 2 possible causes of erythroid aplasia?
- Immune-mediated destruction of RBC precursors
- Feline leukemia virus
What are 3 examples of intrinsic causes of erythroid hypoplasia?
- Myelodysplasia
- Leukemia
- Immune-mediated destruction of erythroid precursors
What are 3 examples of extrinsic causes of erythroid hypoplasia?
- Chronic renal disease
- Endocrine disorders
- Inflammatory disease
