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CVS pharmacology > Angina > Flashcards

Angina Flashcards

(49 cards)

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1
Q

An imbalance between myocardial O2 supply and demand

A

Angina

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2
Q

3 main drugs used in treatment of Angina

A

Organic nitrates
Beta blockers
Ca channel blockers

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3
Q

Organic nitrates

A

Nitroglycerin and isosorbide dinitrate and isosorbide mononitrate

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4
Q

There bioavailability is 10%

A

Nitroglycerin and isosorbide

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5
Q

Has higher bioavailability and long duration of action

A

Isosorbide mononitrate

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6
Q

Metabolized by liver 90%

A

Nitroglycerin and isosorbide dinitrate

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7
Q

It’s excretion is largely by kidney in the form of glucuronide

A

Isosorbide mononitrate

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8
Q

Organic nitrates roles

A

✓Smooth muscle relaxation
✓Dec O2 demand by Dec work of hear
✓Dec preload and after load
✓Inc O2 supply by increasing coronary flow
✓Spasmolytic on smooth muscle

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9
Q

Uses of organic nitrates

A

✓All type of angina
In acute Angina give nitroglycerin or isosorbide dinitrate

✓ In chronic angina give long acting preparations

✓Myocardial infarction
✓Acute heart failure
✓Acute pulmonary edema
✓Spasmolytic

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10
Q

Adverse effects of organic nitrates

A

Inc IOP and glaucoma
Facial flushing
Tachycardia
Postural hypotension
Tolerance
Coronary dependence

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11
Q

Contraindications of organic nitrates

A

✓Sildenafil
✓Hypertrophic obstructive ✓cardiomyopathy right ventricle infarction
✓Volume depletion
✓Severe aortic stenosis

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12
Q

Beta blocker drugs

A

Metaprolol and atenolol

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13
Q

Uses of beta blockers

A

Prophylactic
Myocardial infarction
Safely used with diapetes and peripheral vascular disease

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14
Q

Contraindications of Beta blocker

A

✓Variant angina
✓Should not be stopped suddenly
✓Never combine
✓Bradycardia or asthma

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15
Q

Ca channel blockers

A

Dihydropyridine
Non dihydropyridine

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16
Q

Dihydropyridine

A

Amoldipine (long acting)
Nifedipine ( short acting)

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17
Q

Non dihydropyridine

A

Verapamil
Diltiazem

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18
Q

Ca channel blocker that affects myocardium

A

Verapamil

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19
Q

Ca channel blocker that exert effect on smooth muscles

A

Amoldipine and nifedipine

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20
Q

Ca channel blocker that is intermediate in it’s action

21
Q

Uses of Ca channel blocker

Study These Flashcards
A

All types of angina

22
Q

Angina + arrhythmia we will select which drug?

Study These Flashcards
A

Verapamil or diltiazem

23
Q

Favorable combination in angina+Arrhythmia case

Study These Flashcards
A

Verapamil and nitrate

24
Q

Unfavorable combination in case of angina+ Arrhythmia

Study These Flashcards
A

Verapamil and beta blocker

25
Angina+ hypertension or Bronchial spasm what drug is the best choice?
Nifedipine
26
Favorable combination in case of angina+hypertension or Bronchial asthma
Nifedipine and beta blocker
27
Unfavorable combination in case of angina+hypertension or Bronchial asthma
Nifedipine and nitrate
28
Adverse effects of non dihydropyridine
Bradycardia Heart block Hypotension Heart failure Constipation
29
Adverse effects of dihydropyridine
Inc HR Headache Flushing Ankle oedema
30
✓Drug interactions Verapamil lead to ...
Decrease renal excretion of digoxin
31
Drug interactions Verapamil+ beta blockers lead to ...
Severe cardiac depression
32
Nifedipine+ nitrate lead to
Severe hypotension and tachycardia
33
Potassium channel blocker drug is
Nicorandil
34
A drug which is both arterial and a venous dilator
Nicorandil
35
Adverse effects of nicorandil
Headache Flushing Dizziness
36
Drug used for patients while they are waiting surgery or angioplasty
Nicorandil
37
Metabolic modulators ( cytoprotective)
Na channel blocker Trimetazidine Ivabradine
38
A drug Which is a Na channel blocker
Ranolazine
39
Uses of ranolazine
In chronic angina
40
Adverse effects of ranolazine
Headache Dizziness Constipation Prolongation of QT interval
41
Contraindications of ranolazine
With other drugs that prolong QT interval
42
Drug which inhibits beta oxidation of fatty acids which enhances glucose oxidation
Trimetazidine
43
Uses of trimetazidine
Stable angina Taken orally
44
Drug which inhibits the pacemaker leading to decrease cardiac pacemaker activity
Ivabradine
45
Slowing the heart rate and allowing more time for blood to flow to the myocardium
Ivabradine
46
Drugs that decrease after and preload by arteriodilation
Ca channel blocker Nifedipine and amoldipine
47
By venodilation
Nitrates
48
Coronary vasodilation
Nitrates Ca channel blocker : nifedipine and amoldipine
49
Opening of collaterals and redistribution of blood to ischemic ares
Nitrates

CVS pharmacology (7 decks)

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