Antihypertensive Drugs 2

Question 1

Direct renin inhibitors

Answer 1

Aliskiren

Question 2

Alpha 1 blockers

Answer 2

Prazosin and doxasosin

Question 3

Combined alpha and beta blockers

Answer 3

Labetalol

Question 4

Centrally acting drugs
Alpha 2 adrenoceptor agonists

Answer 4

Alpha adrenoceptor agonists ( clonidine and alpha methyldopa)

Question 5

Vasodilators

Answer 5

Hydralazine

Question 6

Endothelin blockers

Answer 6

Bosentan

Question 7

Dopamine agonists

Answer 7

Fenoldopam

Question 8

From its side effects it is induce lupus erythematosus

Answer 8

Hydralazine

Question 9

Significant baroreceptors homeostatic responses so must be combined with diuretics and beta blockers

Answer 9

Hydralazine and minoxidil

Question 10

Drug that is k channel opener that hyperpolarizes and relaxes vascular smooth muscle

Answer 10

Minoxidil

Question 11

Now it is used to prevent hair loss

Answer 11

Minoxidil

Question 12

From its side effects is hirsutism (hypertrichosis)

Answer 12

Minoxidil

Question 13

Drug that is orally active nonselective blocker of ETA and ETB receptors

Answer 13

Bosentan

Question 14

It is selective ETA blocker

Answer 14

Ambrisentan

Question 15

Drugs used in pregnancy

Answer 15

Labetalol
Alpha methyldopa
Hydralazine

Question 16

Drugs used in hypertension emergencies

Answer 16

Labetalol
Na nitroprusside
Fenoldopam

Question 17

Used in hypertension with benign prostatic hyperplasia

Answer 17

Prazosin

Question 18

From its characteristics is there is no reflex tachycardia

Answer 18

Labetalol

Question 19

It’s major limitation is that it has long half life

Answer 19

Labetalol

Question 20

From its side effects
Nightmares and mental depression

Answer 20

Alpha methyldopa

Question 21

From its side effects
Mild hyperprolactenemia and extrapyrimidal manifestation

Answer 21

Alpha methyldopa

Question 22

From its side effects
Positive coombs test
Auto immune hemolytic anemia
Auto immune hepatitis

Answer 22

Alpha methyldopa

Question 23

Used in hypertension complicated by renal disease

Answer 23

Clonidine

Question 24

Used in reducing anxiety accompanying opiate withdrawal or surgical operations

Answer 24

Clonidine

Question 25

Sudden withdrawal of the drug can lead to rebound hypertension

Answer 25

Clonidine

Question 26

Cause salt and water retention so it is usually combined with diuretics

Answer 26

Clonidine

Question 27

Cause sedation and dry mouth

Answer 27

Clonidine

Question 28

Is a thiazide drugs but has no diuretics effects

Answer 28

Diazoxide

Question 29

Used in acute HF and it is sensitive to light

Answer 29

Na nitroprusside

Question 30

It is the main subtype in smooth muscle

Answer 30

ETA

Question 31

Used in treatment of primary pulmonary hypertension

Answer 31

Bosentan and ambrisentan

Question 32

It release nitric oxide from endothelial cells

Answer 32

Hydralazine

Question 33

It is a direct aretriodilator by opening k channel

Answer 33

Diazoxide

Question 34

It liberates nitric oxide

Answer 34

Na nitroprusside

Question 35

Given in emergency hypertension and acute heart failure

Answer 35

Na nitroprusside

Question 36

Toxicity of na nitroprusside can be reduced by

Answer 36

Sodium thiosulfate or hydroxylamine vit b 12

Question 37

Stimulate peripheral dopamine D1 receptors in renal and mesenteric arteries

Answer 37

Fenoldopam

Question 38

Used as rapid acting vasodilators to treat emergency hypertension

Answer 38

Fenoldopam

Question 39

In patients with pulmonary hypertension and Coronary artery disease which of the following is elevated

Answer 39

Endothelin -1

Question 40

Drug used in treatment of pulmonary hypertension

Answer 40

Bosentan and ambrisentan

Question 41

It inhibits renin activity and RAAS

Answer 41

Aliskiren

Question 42

Treatment of hyperreninemic hypertension

Answer 42

Aliskiren

Question 43

Alpha one blockers

Answer 43

Prazosin

Question 44

Block post synaptic alpha 1 adrenergic receptors leading to arterial and venous vasodilation

Answer 44

Prazoy

Question 45

From its side effects is orthostatic hypotension more with first dose

Answer 45

Prazosin

Question 46

Night mares Sedation Mental depression Mild hyperprolactinemia Positive coombs test are symptoms of which drug

Answer 46

Alpha methyldopa

Question 47

Is a central alpha 2 agonist

Answer 47

Clonidine