Antihyperlipidemic Drugs

Question 1

HMG CoA reductase inhibitors

Answer 1

Statins

Question 2

Inhibitors of hepatic lipid production

Answer 2

Nicotinic acid

Question 3

Activators of plasma lipoprotein lipase

Answer 3

Fibric acid derivatives

Question 4

Inhibitors of intestinal cholesterol absorption

Answer 4

Bile acid binding resins: cholestyramine, colestipol and Ezetimibe

Question 5

Other drugs used in treatment of hyperlipidemia

Answer 5

D- thyroxine
Neomycin
Probucol

Question 6

Mention Statins drugs

Answer 6

Lovastatin
Pravastatin
Svastatin
Fluvastatin
Atorvastatin
Pitavastatine
Rosuvastatin

Question 7

Statins drugs they are prodrugs

Answer 7

Lovastatin
Simvastatin

Question 8

All statins are taken at night except

Answer 8

Pitavastatine
Atorvastatin
Rosuvastatin

Question 9

It’s have life is 12 hours

Answer 9

Pitavastatine

Question 10

It’s half life time is 14 hours

Answer 10

Atorvastatin

Question 11

It’s half life time is 19

Answer 11

Rosuvastatin

Question 12

All statins are metabolized in

Answer 12

Liver

Question 13

Therapeutic uses of statins

Answer 13

Hyperchlolesterolemia
Hyperlipidemia
Acute coronary symptoms

Question 14

Adverse effects of statins

Answer 14

Elevation of serum hepatic enzymes
Myopathy
Rhabdomyolysis
Git disturbances
Cataract
Renal dysfunction

Question 15

Statins potentiate action of

Answer 15

Oral anticoagulant (warfarin)
Oral antidiabetic

Question 16

The CYP3A5 dependent reductase inhibitors are

Answer 16

Lovastatin
Simvastatin
Atorvastatin

Question 17

Drugs that increase effect of CYP3A4

Answer 17

Macrolide
Ketoconazole
Amiodarone
Verapamil

Question 18

Drugs that decrease effect of CYP3A4

Answer 18

Phenytoin
Griseofulvin
Barbiturates
Rifampicin

Question 19

Catabolism of …and …. And to a lesser extent….. Are mediated by CYP2C9

Answer 19

Fluvastatin
Rosuvastatin
Pitavastatine

Question 20

Inhibitors of CYP2C9 are …

Answer 20

Metronidazole
Amiodarone
Cimetidine

Question 21

Drugs that increase plasma levels of fluvastatin and rosuvastatin

Answer 21

Metronidazole
Amiodarone
Cimetidine

Question 22

Drug of choice used with verapamil, ketoconazole and macrolide

Answer 22

Pravastatin
Rosuvastatin

Question 23

A drug which increase blood concentration of most statins by inhibiting glucuronidation of statins

Answer 23

Gemfibrozil

Question 24

Contraindications of statins

Answer 24

Pregnancy
Lactation
Advanced hepatic disease
Advanced renal disease

Question 25

It is the most effective agent for increasing HDL

Answer 25

Niacin( nicotinic acid)

Question 26

Drug which administered orally and excreted in the urine

Answer 26

Niacin

Question 27

Drug which inhibits lipolysis thereby reducing production of free fatty acid

Answer 27

Niacin

Question 28

(In liver ) Drug which inhibits hepatocyte diacylglycerol acyltransferase-2

Answer 28

Niacin

Question 29

(In plasma) Drug that increases lipoprotein lipase activity that increase clearance of VLDL and chylomicron

Answer 29

Niacin

Question 30

Uses of Niacin

Answer 30

Combined hyperlipidemia Hypertriglyceridemia Severe hypercholesterolemia in combination with a resin or reductase inhibitors Statins intolerance

Question 31

Adverse effects of niacin

Answer 31

✓Cutaneous flush ✓git disturbances Nausea Abdominal pain Gastric distress Increase gut motility due to histamine reley ✓Hyperuricemia ✓Reversible elevation in aminotransferase up to twice ✓Carbohydrates tolerance Rarely ✓Platelet deficiency ✓Arrhythmia ✓Macular edema

Question 32

Contraindications of niacin

Answer 32

Peptic ulcers Hepatic disease

Question 33

Niacin may potentiate the action of ...

Answer 33

Antihypertensive agents