Anti Hyperlipidemic Drug2

Question 1

Fibric acid derivatives (fibrates) are

Answer 1

Gemfibrozil
Fenofibrate
Ciprofibrate

Question 2

Drugs that can lower triglycerides level and in some patients LDL as well

Answer 2

Fibric acid derivatives
Gemfibrozil
Fenofibrate
Ciprofibrate

Question 3

One of the following is completely absorbed after oral administration and its absorption is improved when taken with food

Answer 3

Gemfibrozil

Question 4

It is from fibric acid derivatives and it is a prodrug that is hydrolyzed completely in intestine

Answer 4

Fenofibrate

Question 5

From fibric acid derivatives and has very long half life of more than 2 days

Answer 5

Ciprofibrate

Question 6

Agonist for peroxisome proliferator activated receptor alpha

Answer 6

Fibrates

Question 7

Decrease expression of APO -CIII which inhibit lipase activity

Answer 7

Fibrates

Question 8

Increase expression of protein APO A1 &APO A2 so inc HDL conc.

Answer 8

Fibrates

Question 9

Which one from the following is more effective than gemfibrozil in lowering triacylglyceride levels

Answer 9

Fenofibrate

Question 10

Uses of fibrates

Answer 10

Hypertriglyceridemia
Mixed hyperlipidemia in combination with other drugs

Question 11

Mild gastrointestinal disturbances ( nausea, dyspepsia and diarrhea) is the most common adverse effects of …

Answer 11

Fibrates

Question 12

Adverse effects of fibrates are

Answer 12

Mild gastrointestinal disturbances
Gall stones
Myopathy
Myosotis
Hypokalemia
Arrhythmias

Question 13

Risk of myopathy and rhabdomyolysis increases when gemfibrozil is given with …

Answer 13

Statins

Question 14

Fibrates potentiate the action of oral anticoagulant and oral antidiabetic

Question 15

Contraindications of fibrates

Answer 15

Pregnancy and lactation
Severe hepatic or renal dysfunction
Gemfibrozil should not be combined with statins

Question 16

Bile acid binding resins ( sequestrants)

Answer 16

Colestipol
Cholestyramine
Colesevelam

Question 17

Useful only in increase LDL

Answer 17

Bile acid binding resins
Colestipol
Cholestyramine
Colesevelam

Question 18

Uses of bile acid binding resins

Answer 18

Used in primary hypercholesterolemia
When statins are contraindicated and inadequate response to statins

Question 19

Git upset especially constipation

Answer 19

Bile acid binding resins
Colestipol
Cholestyramine
Colesevelam

Question 20

Decrease absorption of fat soluble vitamins at high doses

Answer 20

Bile acid binding resins

Question 21

Form insoluble complex with other drugs

Answer 21

Colestipol
Colesevelam
Cholestyramine

Question 22

Bile acid binding resins drug interactions are

Answer 22

Dec absorption of digitalis, thiazide, warfarin,
Tetracycline, aspirin, pravastatin and fluvastatin

Question 23

A drug doesn’t bind digoxin, warfarin, reductase inhibitors

Answer 23

Colesvelam

Question 24

Cholesterol absorption inhibitors

Answer 24

Ezetimibe

Question 25

Selectively inhibits absorption of dietary and biliary cholesterol in the small intestine

Answer 25

Ezetimibe

Question 26

Causes decrease hepatic cholesterol

Answer 26

Ezetimibe

Question 27

Used as an adjuvant to statins therapy or in statin intolerant patients

Answer 27

Ezetimibe

Question 28

Metabolized in the small intestine and liver with subsequent biliary and renal excretion

Answer 28

Ezetimibe

Question 29

Adverse effects of Ezetimibe

Answer 29

Diarrhoea Abdominal pain Headache Fatigue

Question 30

Contraindications of Ezetimibe

Answer 30

Contraindicated in moderate to severe hepatic insufficiency

Question 31

PCSK9 inhibitors are

Answer 31

Evolocumab Alirocumab

Question 32

Side effects of evolocumab and alirocumab (PCSK9 INHIBITORS)

Answer 32

Injection site reaction Flu like symptoms Neurocognitive problems

Question 33

Inhibit VLDL and triacylglyceride synthesis in liver

Answer 33

Omega 3 fatty acids

Question 34

Adverse effects of omega 3 fatty acids

Answer 34

Git disturbances Fish after taste with fish derived omega 3 Increase risk of bleeding

Question 35

Which one of fibrates can be safely given with statin

Answer 35

Fenofibrate

Question 36

Cause small increase in LDL and HDL

Answer 36

Pufas ( omega 3 fatty acids)