Animal Models

Question 1

Homologous definition

Answer 1

Animal symptoms and causes of condition are identical to humans

Question 2

Isomorphic definition

Answer 2

Animal symptoms are similar but the cause of the symptoms is different

Question 3

Animal model(s) of DiGeorge Syndrome

Answer 3

-Congenital athymia
-Nude mouse and nude streaker mouse

Question 4

Chediak-Higashi syndrome

Answer 4

-Beige mouse (Lyst^bg mutation on chromosome 13)
-Smoke blue persian cats, hereford cattle, brangus cattle, Aleutian mink, killer whales, silver fox

Question 5

X linked agammaglobulinemia

Answer 5

XID mouse

Question 6

NZBxNZWF1 mouse

Answer 6

Model of systemic lupus erythematosus

Question 7

Hirschsprung’s Disease

Answer 7

-Congenital agangliosis –> Megacolon
-Piebald (Ednrb^s-l) and lethal spotting (Edn3^ls) mice and spotting lethal rat

Question 8

Mouse models of obesity

Answer 8

ob/ob (leptin expression) and db/db (leptin receptor function)

Question 9

Adenocarcinoma of the colon

Answer 9

-Intragastic administration of 1,2-dimethylhydrazine (DMH) to weanling Wister rats
-Azoxymethane and DSS administration to APC mutant mice

Question 10

Mouse models of teratomas

Answer 10

129 and A/He strains

Question 11

Diabetes insipidus

Answer 11

Brattleboro rat

Question 12

Diabetes mellitus type I

Answer 12

Mystromys albicuadatus (white-tailed rat), BB Wister rat, NOD mouse, Cricetulus griseus (Chinese hamster)

Question 13

Rat model of obesity

Answer 13

Zucker fa/fa rat (leptin receptor mutation)

Question 14

Interstitial cell tumor

Answer 14

F344 rat

Question 15

Halothane-associated hepatitis

Answer 15

Guinea pig and rat

Question 16

Duchenne muscular dystrophy

Answer 16

Golden retriever muscular dystrophy (DMD mutation), mdx mouse

Question 17

Limb-Girdle muscular dystrophy

Answer 17

Hereditary myopathy in labs, Boston terriers, SJL/J mice

Question 18

Other models of muscular dystrophy

Answer 18

White Pekin ducks (Anas platyrhynhas), turkey, New Hampshire chicken, merino sheep, mink, Syrian hamster

Question 19

Cyclic neutropenia

Answer 19

Gray collie

Question 20

Ehlers-Danlos syndrome

Answer 20

Dogs and mink (connective tissue defect and increased skin laxity)

Question 21

Pelger-Huet Anomaly

Answer 21

Dogs and rabbits (granulocytes don’t develop normal segmentation)

Question 22

GM1, gangliosidnosis

Answer 22

German shorthair pointer, Freisian cattle

Question 23

Von Willebrand’s disease

Answer 23

GSD, mini shnauzers, golden retrievers, Scottish terriers, Dobermans, Poland China swine, chinchilla-Flemish giant rabbit (Factor 8 deficiency)

Question 24

Pyruvate kinase deficiency

Answer 24

Basenji, Beagle (congenital hemolytic anemia)

Question 25

Rabbit models of atherosclerosis

Answer 25

Watanabe heritable hyperlipidemic rabbit (LDL receptor deficiency), St. Thomas Hospital rabbit (LDL increased), KHC rabbit (like WHHL + calcification of coronary artery)

Question 26

Nephroblastoma

Answer 26

IV ENU administration to pregnant rabbit doe on day 18 of gestation

Question 27

Pig model of melanoma

Answer 27

Sinclair minipig

Question 28

Pregnancy toxemia

Answer 28

Patas monkeys (Erythrocebus patas) and guinea pigs

Question 29

Male pattern baldness

Answer 29

Stumptailed macaque (Macaca arctoides)

Question 30

Lymphocytic thyroiditis

Answer 30

-Hashimoto's disease -Callithrix jacchus, Buffalo rat, beagle, BB Wistar rat, obese chicken

Question 31

Leprosy (Hansen's disease)

Answer 31

Sooty Mangabey (Cercocebus toquantus atys), armadillo

Question 32

Aural cholesteatoma

Answer 32

Gerbil

Question 33

Hep B

Answer 33

Woodchuck, Beechy ground squirrel

Question 34

Periodontitis

Answer 34

Rice rat (Oryzomys palustris)

Question 35

Stroke

Answer 35

Gerbil (incomplete circle of Willis)

Question 36

Atrial thrombosis

Answer 36

Aged Syrian hamster (usually L atrium)

Question 37

Cholelithiasis

Answer 37

Richardson ground squirrel (Urocitellus richardsonii)

Question 38

Legionnaire's disease

Answer 38

Guinea pig

Question 39

Klinefelter's syndrome

Answer 39

Tortoiseshell (calico) male cats

Question 40

Porphyria

Answer 40

Cats, cattle, swine

Question 41

Spina bifida

Answer 41

Manx cat

Question 42

Reye's syndrome

Answer 42

Young ferret infected w/ influenza B, given aspirin in water and arginine free diet

Question 43

B-mannosidosis

Answer 43

Nubian goats

Question 44

Ruminant model of melanoma

Answer 44

Angora goats

Question 45

Congenital hyperbilirubinemia

Answer 45

Dubin-Johnson syndrome (conjugated bilirubin): Corriedale sheep Gilbert syndrome (Unconjugated): Shouthdown sheep, Bolivian squirrel monkey Gunn rat

Question 46

Wilson's disease

Answer 46

White perch (Merone americana), Long Evans cinnamon rat, bedlington terrier, sheep

Question 47

Autoimmune disease rodent models

Answer 47

New Zealand black and New Zealand white mice

Question 48

Primary hypertension

Answer 48

SHR rat