Anti-Inflamatory dec 2

Question 1

Acetaminophen is a

Answer 1

Analgesic and antipyretic

Question 2

Acetaminophen MOI

Answer 2

Mechanism of action not well known

Thought to act by inhibiting central and peripheral prostaglandin synthesis

Question 3

Acetaminophen reduced fever by

Answer 3

direct actions on the hypothalamic heat-regulating centers

Question 4

acetaminophen does not

Answer 4

effect COX, so does not affect platelet aggregation or cause GI irritation

Question 5

Ibprofen (NSAID) hard on

Tylenol hard on

Answer 5

kidney (NSAID)

Liver (AcEtaminophen)

Question 6

Tylenol and NSAID are rapidly

Answer 6

absorbed after oral administration

Absorption delayed by food

Question 7

NSAIDs are metabolized by

Answer 7

liver and excreted in urine.

Question 8

Acetaminophen is metabolized by

Answer 8

Liver

Question 9

do not take any more than ___ for acetaminophen per day

Answer 9

3000 mg to 4000 mg

follow label

Question 10

When acetaminophen is taken regularly or in large doses, the stores of

Answer 10

glutathione become depleted, and hepatic necrosis may occur.

Question 11

Overuse of NSAID can stress

Answer 11

kidneys

Question 12

NSAID Most common ADR

Answer 12

GI disturbances

Take with food to reduce GI upset.

Monitor for ulcers and GI bleed.

Question 13

NSAID can cause

Answer 13

acute renal insufficiency

Question 14

NSAID inhibit

Answer 14

platelet aggregation and may increase bleeding time

Question 15

NSAID cause fluid

Answer 15

retention and peripheral edema

Question 16

Indomethacin (NSAID): may

Answer 16

aggravate depression or other psychiatric disturbances

Question 17

COX-2 inhibitors and all NSAIDs have

Answer 17

Black Box warning for patients about cardiovascular risk.

All NSAIDs may increase the risk of a heart attack or stroke

Question 18

Acetaminophen ADR acute hepatic necrosis occurs with

Answer 18

with doses of 10 to 15 g.

Doses above 25 g are usually fatal.

Question 19

Acetaminophen poisoning treatment

Answer 19

Refer to poison center.
Get acetaminophen level.
Oral N-acetylcysteine is a specific antidote for acetaminophen toxicity.

Question 20

Rheumatoid arthritis

Use and follow

Answer 20

Use NSAIDs or celecoxib to reduce joint pain and swelling.
Follow American College of Rheumatology suggestions for treatment.

There is increased risk for complications, so monitor closely.

Question 21

Osteoarthritis use

Answer 21

Acetaminophen or NSAIDs can be used for pain.

Question 22

Gout use

Answer 22

Indomethacin, naproxen, and sulindac

Question 23

Mild to moderate pain use

Answer 23

Non-opioid analgesia includes NSAIDs and acetaminophen.

Ibuprofen and naproxen are most commonly used.

Question 24

Primary dysmenorrhea use

Answer 24

NSAIDs (ibuprofen or naproxen) are the drugs of choice.

Question 25

Tendonitis and bursitis use

Answer 25

Indomethacin SR, naproxen, and sulindac are used.

Question 26

Fever use

Answer 26

Ibuprofen is the drug of choice.

Question 27

Acetaminophen | Drug of choice for

Answer 27

mild to moderate pain in: Pregnancy Patients with history of GI bleed Aspirin allergy, blood coagulation disorders, upper GI disease

Question 28

Acetaminophen | Drug of choice for fever in

Answer 28

older adults (not as hard on kidneys) ] Children, infants younger than 6 months of age Especially children with fever during flu-like illness

Question 29

NSAIDs | monitoring

Answer 29

Renal function with long-term therapy GI ulcer or GI bleed CBC prior to initiation of therapy and annually thereafter

Question 30

Acetaminophen | Monitoring

Answer 30

Dosing for overdosing with self-medication | Liver function if on high-dose or long-term therapy

Question 31

NSAID patient education

Answer 31

Take as directed. Limit alcohol consumption. Maximum acetaminophen dose is 3 g/24 hours.

Question 32

NSAID ADR

Answer 32

Report GI upset or “coffee ground” emesis

Question 33

Aspirin and Salicylates action

Answer 33

These drugs have analgesic, anti-inflammatory, antipyretic, and antiplatelet activities

Question 34

Aspirin and Salicylates | The anti-inflammatory and analgesic activities are mediated through

Answer 34

inhibition of prostaglandin synthesis.

Question 35

Aspirin irreversibly inhibits

Answer 35

platelet aggregation.

Question 36

Aspirin | Rapidly and completely

Answer 36

Aspirin Rapidly and completely Widely distributed to all tissues Metabolized by liver and eliminated via urine

Question 37

Aspirin: ADRs GI

Answer 37

ulcers, bleeding, iron-deficiency anemia

Question 38

ASA is what at higher levels

Answer 38

ototoxic

Question 39

ulcers, bleeding, iron-deficiency anemia

Answer 39

or chickenpox associated with the development of Reye’s syndrome

Question 40

ASA Avoid after

Answer 40

Avoid after

Question 41

ASA pregnancy category

Answer 41

D

Question 42

Aspirin Poisoning - Leathel dose

Answer 42

10 to 30 g.

Question 43

what happens with ASA poisoning

Answer 43

respiratory alkalosis

Question 44

ASA trement includes

Answer 44

induction of emesis or gastric lavage to remove any unabsorbed drug from the stomach if less than 2 hours from ingestion.

Question 45

ASA Alkalinizing urine may increase

Answer 45

excretion

Question 46

ASA Hemodialysis may be used for

Answer 46

Hemodialysis may be used for sever poisoning

Question 47

ASA fever

Answer 47

Aspirin is effective antipyretic | Do not use in pregnant patients or children.

Question 48

what is the gold standard for mild ot moderate pain

Answer 48

ASA

Question 49

ASA rheumatoid arthritis

Answer 49

Aspirin is the gold standard. Margin is narrow between a good therapeutic level and toxicity in treating patients with RA. Juvenile patients with RA take aspirin.

Question 50

ASA osteoarthritis

Answer 50

works well to treat pain