Flashcards in Anti-Inflammatory and Immunosuppressant Drugs Deck (22)
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1
What does NSAID stand for
non steroidal anti inflammatory drugs
2
What do NSAIDs decrease the production of
prostaglandins and thromboxane
3
What are the properties of NSAIDs
anti-inflammatory, analgesic, antipyretic
4
What is the effect of prostaglandins in damaged and inflammed tissue
sensitises nociceptors to inflammatory mediators
5
What is the effect of the anti-inflammatory property of NSAIDs
decrease vasodilation
6
What are the two isoforms of COX
COX1 and COX2
7
Which COX isoform exhibits inducible expression
COX2
8
Where is COX1 expressed
platelets, stomach, colon, most tissues
9
Where is COX2 expressed
most cells, kidney, inflammatory cells after stimulation
10
What can stimulate inflammatory cells to express COX2
cytokines, growth factors, tumor promoters
11
What are the side effects of NSAIDs
renal failure, liver damage, skin rashes, bronchospasm, affects the gut
12
What is the function of prostaglandins in the gut
inhibit acid secretion and protect mucosa
13
Which NSAID has the highest risk of GI complications
azapropazone
14
What is an undesirable side effect from COX1 inhibition by NSAIDs
gastrotoxicity
15
What is an undesirable side effect from COX2 inhibition by NSAIDs
increase BP, salt retention,
16
What aspirin bind to in COX
covalently to COX residue
17
What does aspirin binding to Ser residue in COX prevent
arachadonic acid from reaching the cyclo-oxygenase site
18
What diseases can aspirin reduce the risk of
colonic and rectal cancer, alzheimer's
19
Where is paracetamol metabolised
liver
20
What type of drug is paracetamol
competitive inhibitor
21
What type of drug is aspirin
suicide inhibitor - irreversible
22
