Anti-Inflammatory and Immunosuppressant Drugs Flashcards Preview

BMS 242 Core Physiology and Pharmacology > Anti-Inflammatory and Immunosuppressant Drugs > Flashcards

Flashcards in Anti-Inflammatory and Immunosuppressant Drugs Deck (22)
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1

What does NSAID stand for

non steroidal anti inflammatory drugs

2

What do NSAIDs decrease the production of

prostaglandins and thromboxane

3

What are the properties of NSAIDs

anti-inflammatory, analgesic, antipyretic

4

What is the effect of prostaglandins in damaged and inflammed tissue

sensitises nociceptors to inflammatory mediators

5

What is the effect of the anti-inflammatory property of NSAIDs

decrease vasodilation

6

What are the two isoforms of COX

COX1 and COX2

7

Which COX isoform exhibits inducible expression

COX2

8

Where is COX1 expressed

platelets, stomach, colon, most tissues

9

Where is COX2 expressed

most cells, kidney, inflammatory cells after stimulation

10

What can stimulate inflammatory cells to express COX2

cytokines, growth factors, tumor promoters

11

What are the side effects of NSAIDs

renal failure, liver damage, skin rashes, bronchospasm, affects the gut

12

What is the function of prostaglandins in the gut

inhibit acid secretion and protect mucosa

13

Which NSAID has the highest risk of GI complications

azapropazone

14

What is an undesirable side effect from COX1 inhibition by NSAIDs

gastrotoxicity

15

What is an undesirable side effect from COX2 inhibition by NSAIDs

increase BP, salt retention,

16

What aspirin bind to in COX

covalently to COX residue

17

What does aspirin binding to Ser residue in COX prevent

arachadonic acid from reaching the cyclo-oxygenase site

18

What diseases can aspirin reduce the risk of

colonic and rectal cancer, alzheimer's

19

Where is paracetamol metabolised

liver

20

What type of drug is paracetamol

competitive inhibitor

21

What type of drug is aspirin

suicide inhibitor - irreversible

22

What can aspirin be used for

reduce risk of arterial thrombosis