Anti-Inflammatory and Immunosuppressant drugs II Flashcards Preview

BMS 242 Core Physiology and Pharmacology > Anti-Inflammatory and Immunosuppressant drugs II > Flashcards

Flashcards in Anti-Inflammatory and Immunosuppressant drugs II Deck (50)
Loading flashcards...
1

What is rheumatoid arthritis

auto immune disease

2

Who does rheumatoid arthritis affect

usually women, 40-60 age range

3

What are the symptoms of rheumatoid arthritis

swelling of joints, pain, stiffness in morning, poor sleep

4

What are drugs used to treat rheumatoid arthritis referred to as

DMARDs

5

What is the most common treatment for rheumatoid arthritis

methotrexate

6

What class of drug is methotrexate

antagonist

7

What is the function of methotrexate

suppresses immune system function

8

What is a disadvantage of methotrexate

cytotoxic

9

What is the start of the pathway for rheumatoid arthritis

activated TH1 cells

10

What is the function of activated TH1 cells

activate other immune cells

11

What do macrophages release

IR1 and TNF-a

12

What are IR1 and TNF-a

pro-inflammatory cytokines

13

What does activation of osteoclast and fibroblasts cause

erosion of cartilage, joints and bones

14

What does methotrexate inhibit

activation of TH1 cells

15

What is ciclosporin

immuno suppressant drug

16

What does ciclosporin bind to

cyclophilin

17

Where is cyclophilin found

cytosol

18

What is cyclophilin a member of the family of

immunophilins

19

What is a function of immunophilins

control transcription by binding to calcineurin

20

What is calcineurin

calcium activated phosphatase

21

What is the function of IL2

activates TH1 cells

22

What do immuno-suppressant drugs inhibit

induction phase of inflammatory response

23

What do ciclosporin and glucocorticoids inhibit

transcription of pro-inflammatory cytokines

24

What are mab drugs

monoclonal antibody based drugs

25

What is the function of adalimumab

inhibit TNF

26

What is the effect of inhibiting TNF

TNF no longer binds to receptor - immune function reduced

27

Describe decoy receptors

engineer protein that mimics extracellular binding domain of protein

28

What is asthma

chronic inflammatory disease

29

What are the two phases in asthma

early phase - bronchospasm, late phase - inflammation

30

Describe late phase of asthma response

severe, prolonged, combined activity of immune cells

31

What can an allergic reaction to an injected substance cause

anaphalatic shock

32

What is swelling caused by in the late phase of a reaction

infiltration of large number of immune cells

33

What antibody mediates hypersensitivity

IgE

34

Where are mast cells found

skin and mucous surfaces

35

What gives rise to anaphaltic shocks

specialised mast cells - basophils

36

Where are basophils located

blood

37

What is the natural role of IgE

prevent parasitic infections

38

What do mast cells contain

granules

39

What do the granules in mast cells contain

histamine

40

Overactivity of what is associated with asthma

TH2 cells

41

What do TH2 cells interact with

B cells

42

What do B cells produce

antibodies

43

What can asthma be treated with

salbutamol, glucocorticoids

44

What do glucocorticoids inhibit

production of cytokines

45

What happens in early phase reaction

smooth muscle contracts - mediated by release of histamine

46

What increases vascular permeability

release of prostaglandins

47

What is swelling in lungs in early phase reaction caused by

increased vasculature permeability

48

What is secreted immediately during an asthma attack

cytokines and chemokines

49

What treats the immediate phase symptoms of asthma attack

salbutamol

50

Name side effects of chronic steroid use

easy bruising, poor wound healing, increased abdominal fat, hypertension