Pharmacokinetics Flashcards Preview

BMS 242 Core Physiology and Pharmacology > Pharmacokinetics > Flashcards

Flashcards in Pharmacokinetics Deck (23)
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1

What do drug effects depend on

mechanism of action, physiochemical properties,

2

What does the concentration of drug when given depend on

absorption, distribution, metabolism, excretion

3

What is pharmacokinetics

branch of pharmacology concerned with the movement of drugs in the body

4

What does drug metabolism and pharmacokinetics reduce when its integrated into drug development

attrition

5

How are drugs absorbed and distributed through the body

diffusion and transfer through bloodstream

6

What does the movement of drugs between compartments usually involve

penetration of lipid diffusion barriers

7

What molecules diffuse freely through lipids

non polar uncharged molecules

8

What does diffusion of drugs through lipids increase

rate of absorption from gut, penetration into brain, renal elimination

9

What is the most important determinant of pharmacokinetic characteristics of a drug

lipid solubility

10

What influences drug absorption in the body

access to desired site of action

11

How are oral or rectal drugs excreted

faeces

12

How are inhaled drugs excreted

expired air

13

What factors affect absorption of drugs

method of administration, molecular weight, lipid solubility, pH and ionisation

14

What does molecular weight of drugs effect

rate of diffusion

15

What does lipid solubility of drugs effect

ability to cross lipid membrane by diffusion

16

What happens to weak acids at low pH

un-ionized

17

How can pH affect drug movement

affect the steady state distribution of drugs between aqueous compartments

18

What do basic pH environments favour

dissociation of acids

19

What can weak acids become trapped in in basic environments

basic compartments e.g. renal tubules

20

What is the effect of increasing plasma pH on weakly acidic drugs

causes extraction from CNS into plasma where they get 'trapped'

21

What is the effect of trapping weakly acidic drugs

neurotoxicity

22

True or False - carrier mediated transport can affect drug absorption

true

23

What are genetic variants of organic cation transporter 1 associated with

different responses to metformin in healthy humans