Pharmacokinetics II Flashcards Preview

BMS 242 Core Physiology and Pharmacology > Pharmacokinetics II > Flashcards

Flashcards in Pharmacokinetics II Deck (45)
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1

What are the major body compartments

extracellular fluid, intracellular fluid, transcellular fluids, fat

2

Which type of drugs are effective

free drugs

3

What type of drugs does fat have an important impact on

lipophilic drugs

4

What is drug distribution based on

permeability and lipid solubility

5

What is meningitis

bacterial infection of the CNS

6

What is domperidone

antagonist of dopaminergic agonist receptors in chemoreceptor trigger zone

7

What regulates drug access to the CNS

blood brain barrier

8

Describe a junction in the CNS

endothelial cells line blood vessels and form tight junctions

9

What are tight junctions impermeable to

water soluble molecules

10

What can cross the BBB easily

lipid soluble molecules - ethanol and caffeine

11

What can happen to tight junctions during inflammation

become leaky

12

What can meningitis be treated with

iv penicillin

13

What other factors can influence drug distribution and elimination

binding to plasma proteins, partition into specific tissues

14

What does albumin bind to

mainly acidic drugs

15

What are the two main biochemical reactions for drug metabolism

catabolic reactions, synthetic (anabolic) reactions

16

What do catabolic reactions produce

more reactive compounds

17

What do anabolic reactions involve

conjugation

18

What do anabolic reactions produce

inactive product

19

Where does drug metabolism occur

liver

20

What affect can metabolism have on drug action

alter or prolong pharmacological drug action

21

What must drugs cross in order to be metabolised

plasma membrane

22

What speeds up drug metabolism

microsomal enzymes - cytochrome p450 in the liver

23

What are the stages of aspirin elimination

drug forms a derivative - then forms a conjugate

24

How can a drug form a derivative

oxidation, hydroxylation, dealkylation, deamination, hydrolysis

25

How does aspirin form its derivative

OCOCH3 group on aspirin is hydroxylated

26

What is the derivative of aspirin

salicylic acid

27

What hydroxylates aspirin into salicylic acid

p450 enzymes

28

What is the conjugate of aspirin

glucoronide

29

Name three important p450 enzymes

CYP1, CYP2, CYP3

30

What are CYP1, CYP2 and CYP3 involved in

drug and steroid metabolism