Anti-Inflammatory Drugs Flashcards Preview

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Flashcards in Anti-Inflammatory Drugs Deck (47):
1

Histamine

Released by Mast cell IgE mediated degranulation, and from basophils. Leads to redness, heat, swelling, and airway constriction acid secretion, urticaria. No chemotaxis.

2

LTB4

Leukotriene which is Chemotactic for neutrophils, reduces pain threshold.

3

LTC4

Causes bronchoconstriction, increased vascular permeability,

4

LTD4

Causes bronchoconstriction, increased vascular permeability

5

LTE4

Causes bronchoconstriction, increased vascular permeability

6

PGD2

Prostaglandin receptor leading to bronchoconstriction. Produced by mast cells.

7

PGE2

Prostaglandin receptor causing FEVER(IL-1 mediated) Vasodilation, increased vascular permeabilty and pain.

8

PGF2

prostaglandin receptor which leads to uterine contraction, and bronchoconstriction.

9

PGI2

Prostaglandin receptor causing Vasodilation, increased vascular permeabilty and pain, and opposes platelet aggregation.

10

TXA2

Thromboxane which leads to bronchoconstriction, platelet aggregation, and vasoconstriction.

11

Bradykinin

Does everything(leads to infllamation, redness, swelling, heat, pain). It is also a strong VASODILATOR resulting in hypotension. not a chemoattractant

12

Kallidin

Kinin which Does everything. It is also a strong VASODILATOR resulting in hypotension. not a chemoattractant

13

Diphenhydramine

1st generation Antihistamine Prevents histamine induced bronchoconstriction, contraction of GI smooth muscle, hives, itch, pain. NOT pumped out of CNS. Low GI side effects. Drying of secretions. Has antimuscarinic properties.

14

Chlorpheniramine

1st generation Antihistamine Prevents histamine induced bronchoconstriction, contraction of GI smooth muscle, hives, itch, pain. Not as sedating as diphenhydramine. Drying of secretions. Has antimuscarinic properties.

15

Cetirizine

2nd Generation Antihistamine. Has minimal anticholinergic properties, Does not cause sedation or drying of secretions. Subject for P-Glycoprotein Efflux pump.

16

Fexofenadine

2nd Generation Antihistamine. Has minimal anticholinergic properties, Does not cause sedation or drying of secretions. Subject for P-Glycoprotein Efflux pump.

17

Loratadine

2nd Generation Antihistamine. Has minimal anticholinergic properties, Does not cause sedation or drying of secretions. Subject for P-Glycoprotein Efflux pump.

18

Zileuton

Inhibits 5- lipoxygenase and prevents synthesis of LTB4, increasing pain threshold, may decrease use of beta agonsists in asthma, AE: CYP450, hepatotoxicity.

19

Zafirlukast

Leukotriene receptor antagonist (LTD receptor), AE: inhibits a cytochrome P450 isoenzyme and may cause significant drug interactions. Used in asthma.

20

Montelukast

Leukotriene receptor antagonist,(LTD4 receptor), Used in Asthma. daily admin w/o meal restrictions.

21

Aspirin

Irreversible COX inhibitor. Has more effects on platelets because they don't have a nucleus. AE: bleeding and GI problems, tinnitus, asprin hypersensitivity(rhinitis, urticaria, asthma, laryngeal edema) due to shift to lypoxegenase shift. Rye syndrome: encephalopathy and fatty liver following viral infection in kids.

22

Ibuprofen

Nonselective COX inhibitor, fewer GI side effects than aspirin.

23

Naproxen

Aleve, Nonselective COX inhibitor.

24

Ketorlac

More potent NSAID, Nonselective COX inhibitor, used for analgesia, but is also anti-inflammatory.

25

Indomethacin

MOST potent NSAID, Nonselective COX inhibitor, AE: severe frontal headache and blood disorders

26

Sulindac

More potent NSAID, Nonselective COX inhibitor

27

Ketoprofen

More potent NSAID Nonselective COX inhibitor, related to ibuprofen

28

Piroxicam

More potent NSAID once a day admin, can cause dose related serious GI bleeding.

29

Celecoxib

Selective COX II inhibitor.

30

Acetaminophen

Not an NSAID, Is a weak inhibitor of COX, and has minimal anti-inflammatory effect. Analgesic and antipyretic. AE: hepatotoxicity.

31

Cortisol

Anti-inflammatory Steroid,

32

Hydrocortisone

Anti-inflammatory Steroid

33

Prednisone

Anti-inflammatory steroid

34

Methylprednisone

Anti-inflammatory steroid

35

Betamethasone

Anti-inflammatory Steroid, long acting

36

Dexamethasone

Anti-inflammatory Steroid, Long acting.

37

Cyclosporine

Immunosuppresive agent, Binds cyclophilin receptor inhibiting calcineurin activity, blocking dephosphorylation events for T cell activation. Liver met. AE: Drug interactions, renal toxicity up to 75%. Used long term for transplants.

38

Tacrolimus (FK506)

Immunosuppressive, binds FKB506 resulting in inhibition of calcineurin. Blocks the dephosphorylation events for cytokine expression and T cell activ. 100X more potent than cyclosporine. AE: nephrotoxicity.

39

Sirolimus

Antiproliferative drug used for organ transplant rejection. Binds FKBP to inhibit mTOR and stop cell cycle progression of B and T cells. AE: dose dependant increase in cholesterol and Triglycerides, nephrotoxicity, increased lymphomas and infections, CYP3A4.

40

Mycophenolate

Antimetabolic drug, used in organ transplant, metabolite is inhibitor of inosine monophosphate dehydrogenase, preventing guanine synthesis. B and T cells are highly dependant on this pathway for proliferation. AE: hematologic and GI tox. Leukopenia, diarrhea and vomiting.

41

Anti-thymocyte Globulin

Immunosuppressive, Ig binds thymocytes in circulation resulting in lymphopenia and impaired T cell immune response. AE: toxicity due to Ig being recognized as foriegn: i.e. serum sickness, nephritis, occasional anaphylaxis

42

Muromonab-CD3

Immunosuppressive, used for whole organ transplants. Is an antibody whcih binds CD3(t-cell receptor). AE: cytokine release syndrome, give corticosteroids first.

43

Daclizumab

Immunosuppressive. Humanized, Anti-IL-2 receptor for activated T cells, blocking IL2 activated T cell activation events. Used in organ transplantation. AE: few, common antibody side effects

44

Basiliximab

Immunosuppressive. Humanized, Anti-IL-2 receptor for activated T cells, blocking IL2 activated T cell activation events. Used in organ transplantation. AE: few, common antibody side effects

45

Phenylephrine

Alpha1 agonist, leads to vasoconstriction

46

Theophylline

adenosine receptor antagonist, increases cAMP, inhibits leukotriene synthesis

47

omalizumab

Antibody to IgE, increased risk of parasitic infections. expensive.