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Flashcards in Week 3 Deck (28):
1

Th1 differentiation factors

Induced by IL-12 and IFN-α.

2

Th1 Secretion

Lymphokines including IFNγ which draws in and classically activates (M1) macrophages

3

M1 macrophage Activation

Activated by Th1 releasing IFNγ.

4

M1 macrophage secretion

cytokines include tumor-necrosis factor alpha (TNFα) and IL-1 to mediate inflammation

5

Th 17 cells induction

induced by TGF-β and IL-21

6

Th 17 cells function

IL-17 release and main job is mediating inflammation and maintaining the integrety of mucosal surfaces

7

Th2 Cells function

circulate through the blood until they encounter their antigen, secrete IL-4 and IL-13 which alternatively activates(M2) macrophages and are more involved in healing. IL- also attracts eosinophils, and stimulates B cells to produce IgE.

8

Tfh function

helps to activate B cells differentiate into plasma cells. Helps in differentiation of antibodies. Promotes IgA in the gut and IgG in the spleen.

9

Th 2 induction

DC 2 and Il4

10

Treg induction

TgFbeta

11

Treg function

Suppresses Th1, Th2, Th17, Tfh by contact and soluble factors (IL-10, TGFBeta)

12

Cytotoxic (killer) T cells

Detects MHC class I and kills cells by binding to CD 95 on the target cell, leading to apoptosis, or it can secrete granzymes and other proteases called perforins which trigger apoptosis.

13

Cytotoxic T cell Induction

Come in contact with a DC, and need IL-2 to be produced from Th1, and for conversion into memory cells it needs IL-21.

14

Dendritic cells

Has both MHC class I and II, and can activate both CD4+ and CD8+ T cells.

15

Memory T cells

Are after a response to antigen, T cell number declines, and are memory T cells which can replace themselves as well as rapidly differentiate into effector cells when re-exposed to low antigen concentrations

16

CD3

A complex of molecules associated with the TCR. It is important in downstream signaling after T cell receptor binds its antigen.

17

CD 4 molecule

has four Ig-like domains, binds to a conserved region on class II antigen, binds to signal transduction molecule p56 and also binds to the zeta chains of CD3.

18

CD8 Molecule

alpha beta heterodimer or aa homodimer with one Ig-like domain held together by a disulfide bond. Binds to a conserved Class I antigen

19

CD4+ T cell CD2 binds

LFA-3

20

CD4+ T cell TCR-CD3 binds

MHC class II

21

CD4+ T cell p56kk CD4 binds

MHC class II

22

CD4+ T cell CD 28 binds

CD 80 or CD 86

23

CD4+ T cell LFA-1 binds

Binds ICAM-1

24

CD8+ T cell CD2 binds

LFA-3

25

CD8+ T cell TCR-CD3 binds

ClassI MHC

26

CD8+ T cell CD8 binds

MHC class I

27

CD8+ T cell CD 28 binds

CD80 or CD 86

28

CD8+ T cell LFA-1 binds

ICAM-1