Antineoplastic Topics Flashcards Preview

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Flashcards in Antineoplastic Topics Deck (17):
1

Efflux type pump for removal of drugs, especially natural drugs

P- glycoprotein

2

Folate Analogs

Trex METHOTREXATE, PEMETREXED,
PRALATREXATE

3

Antimetabolites

CITABINE and Arabine
CAPECITABINE, CLADARABINE,
CYTARABINE, FLUDARABINE,
GEMCITABINE

4

Platinum containing cross linking agents

Platin

5

Anthracycline antibiotics

RUBICIN
DAUNORUBICIN, DOXORUBICIN,
EPIRUBICIN, IDARUBICIN

6

Nitrosoureas

MUSTINE
CARMUSTINE (BCNU), LOMUSTINE
(CCNU)

7

Taxanes

TAXEL
PACLITAXEL, CABAZITAXEL,
DOCATAXEL

8

Antibiotics

MYCIN
BLEOMYCIN, MITOMYCIN

9

Camptothecins

TECAN
IRINOTECAN, TOPOTECAN

10

Vinca alkaloids

VIN...INE
VINBLASTINE, VINCRISTINE,
VINORELBINE

11

Signal transduction inhibitors (block the
actions of tyrosine kinases)

NIB
DASATINIB, ERLOTINIB, GEFITINIB,
IMATINIB, LAPATANIB, NALOTINIB,
PAZOPANIB, SORAFENIB, SUNITINIB

12

Protein inhibitors

IB
BORTEZOMIB

13

Vitamin B12

Is an important cofactor required for DNA synthesis and for maintenance of neurons and RBCs. It is critical cofactor in the generation of tetrahydrofolate from liver stores of tetrahydrofolate.

14

Reduced Folate carrier

Is a high capacity, low affinity Transporter. Leukovorin is transported better than folate.

15

Folate receptor

High affinity, low capacity system. Pinocytoses receptor to draw folate into the cell. Takes up folate better than methotrexate.

16

Polyglutamination

Keeps folate in cell by adding glutamate on it. It also increases affinity for target cells. Cancer cells are better at polyglutamination

17

Resistance to Alkylating agents

increase DNA repair, express gluathione (trapping agent)