Flashcards in Antineoplastic Topics Deck (17):
Efflux type pump for removal of drugs, especially natural drugs
Trex METHOTREXATE, PEMETREXED,
CITABINE and Arabine
Platinum containing cross linking agents
CARMUSTINE (BCNU), LOMUSTINE
Signal transduction inhibitors (block the
actions of tyrosine kinases)
DASATINIB, ERLOTINIB, GEFITINIB,
IMATINIB, LAPATANIB, NALOTINIB,
PAZOPANIB, SORAFENIB, SUNITINIB
Is an important cofactor required for DNA synthesis and for maintenance of neurons and RBCs. It is critical cofactor in the generation of tetrahydrofolate from liver stores of tetrahydrofolate.
Reduced Folate carrier
Is a high capacity, low affinity Transporter. Leukovorin is transported better than folate.
High affinity, low capacity system. Pinocytoses receptor to draw folate into the cell. Takes up folate better than methotrexate.
Keeps folate in cell by adding glutamate on it. It also increases affinity for target cells. Cancer cells are better at polyglutamination