Flashcards in Week 2 Immunity Deck (47):
CD281 detects triacyl lipoprotein from gm+ bacteria
CD282 detects triacyl lipoprotein from gm+ bacteria
Detects dsRNA and viruses. Does not go through MyD88.
Detects LPS Gm- bacteria Cd284
Detects flagellin protein
ssRNA in endosomes
CPG DNA- bacterial and viral genome synthesis products
CD290, unknown function
Expression of pro-inflammatory genes
•Production of prostaglandins and other leukotrienes
•Production of interleukins and other cytokines
Other immune process helping functions
Formation of HOCl form H2O2
Uses the Fe containing enzyem myeloperoxidase mostly in neutrophils.
Chronic Granulomatous disease
Phagocytes have genetic defects in "NADPH oxidase" and most infections in these patients are catalase positive because they can break down the H2O2 produced by our cells.
MHC class I
Are recognized by CD8+ killer T cells. Display internal proteins which may help to display viral infection.
MHC Class II
Recognized by CD4+ helper T cells. Display antigen of phagocytosed products on the cell surface of Monocytes, dendritic cells, b cells.
Type 1 Ht cell. recognizes antigen and makes a lymphokine to attract macrophages to clean up antigen/ infection.
main role is focused on inflammation, are more powerful than Th1. Problems with these leads to autoimmunity.
Stimulate macrophages to become able to wall off pathogens and promote healing. Important in parasite immunity.
Follicular helper T cells. Stimulated by antigen, migrate from T cell areasof lymph nodes into the B cell follicles where they help in B cell activation and making antibody subclasses.
make cytokines that suppress the activation and fx. of Th1, Th17, an Th2 cells to keep immune system in check.
Cytotoxic or killer T cells. Destroy any body cell they identify as having a foriegn or abnormal antigen on its surface.
Present on Th1, Th2, Th17, Tfh, and Treg which increases their affinity for antigen to help them get activated.
Present on Ctyotoxic T cells, helps to Bind MHC class 1.
two adjacent molecules can lead to complement activation, can attract phagocytic cells.Only antibody which can cross placenta.
Pentameric Ig, activates complement, first antibody to appear in blood after infection, then turns to IgG
main form of antibody inserted into B cell membranes as their antigen receptor.
Antibody in fluids and mucous membranes. Has secretory component to make it resistant to degredative enyzmes. First line defense. has two of them together.
Associated with Mast cells. Causes mast cell release of histamine, prostaglandins, leukotrienes, producing symptoms of allergy. Real role is resistance to parasites.
Antibody Concentration in blood high to low
Type I hypersensitivity
Too much IgE causing mast cell degranulation. Can be asthma, allergic reaction to bee sting, allergic reaction.
Type II hypersensitivity
Autoimmunity due to antibodies which can react against self. Ex. hemolytic disease of newborn, myasthenia gravis.
Type III hypersensitivity
Occur when make antibody against soluble antigen. Commonly leads to arthritis, glomerulonephritis, pleurisy, rash. Also see serum sickness.
Type IV Hypersensitivity
Cell mediated hypersensitivty caused by CD4+ cells, can be autoimmune or bystander injury. Ex. reation with nickel, tuberculin reaction, chron's disease.
alpha helical peptides which are bactericidal.
Beta strand peptides connected by disulfide bonds. look like a fence. There are 2 classes. They all lead to excretion out of the cells and into membranes or viral envelopes dimerize and lead to holes in the membranes.
Cell response to TLR signaling
Activation of NF-kB and expression of pro-inflammatory genes.
leads to the activation of phagocytic cells and NK cells.
produced by macrophages and other mononuclear phagocytes. Leads to induce fever, apoptotic cell death, cachexia, inflammation
dependant on what the heavy chain is. Can be GAMED, but still reacts with the same things.
contains the FAB region for antigen/ epitope recognition. Can either be a kappa or lambda type. One cell always produces the same light chain.
Slight differences in the amino acid secuences of their H chain C regions, the 5 main classes of immunoglobulins.
IgG1 IgG2 IgG3 IgG4