Week 2 Immunity Flashcards Preview

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Flashcards in Week 2 Immunity Deck (47):
1

TLR1

CD281 detects triacyl lipoprotein from gm+ bacteria

2

TLR2

CD282 detects triacyl lipoprotein from gm+ bacteria

3

TLR3

Detects dsRNA and viruses. Does not go through MyD88.

4

TLR4

Detects LPS Gm- bacteria Cd284

5

TLR5

Detects flagellin protein

6

TLR6

bacterial lipoproteins

7

TLR7

ssRNA in endosomes

8

TLR8

oligonucleotides

9

TLR9

CPG DNA- bacterial and viral genome synthesis products

10

TLR10

CD290, unknown function

11

NFkB

Expression of pro-inflammatory genes
•Production of prostaglandins and other leukotrienes
•Production of interleukins and other cytokines
Other immune process helping functions

12

Formation of HOCl form H2O2

Uses the Fe containing enzyem myeloperoxidase mostly in neutrophils.

13

Chronic Granulomatous disease

Phagocytes have genetic defects in "NADPH oxidase" and most infections in these patients are catalase positive because they can break down the H2O2 produced by our cells.

14

MHC class I

Are recognized by CD8+ killer T cells. Display internal proteins which may help to display viral infection.

15

MHC Class II

Recognized by CD4+ helper T cells. Display antigen of phagocytosed products on the cell surface of Monocytes, dendritic cells, b cells.

16

Th1

Type 1 Ht cell. recognizes antigen and makes a lymphokine to attract macrophages to clean up antigen/ infection.

17

Th17

main role is focused on inflammation, are more powerful than Th1. Problems with these leads to autoimmunity.

18

Th2

Stimulate macrophages to become able to wall off pathogens and promote healing. Important in parasite immunity.

19

Tfh

Follicular helper T cells. Stimulated by antigen, migrate from T cell areasof lymph nodes into the B cell follicles where they help in B cell activation and making antibody subclasses.

20

Treg

make cytokines that suppress the activation and fx. of Th1, Th17, an Th2 cells to keep immune system in check.

21

CTL

Cytotoxic or killer T cells. Destroy any body cell they identify as having a foriegn or abnormal antigen on its surface.

22

CD4

Present on Th1, Th2, Th17, Tfh, and Treg which increases their affinity for antigen to help them get activated.

23

CD8

Present on Ctyotoxic T cells, helps to Bind MHC class 1.

24

IgG

two adjacent molecules can lead to complement activation, can attract phagocytic cells.Only antibody which can cross placenta.

25

IgM

Pentameric Ig, activates complement, first antibody to appear in blood after infection, then turns to IgG

26

IgD

main form of antibody inserted into B cell membranes as their antigen receptor.

27

IgA

Antibody in fluids and mucous membranes. Has secretory component to make it resistant to degredative enyzmes. First line defense. has two of them together.

28

IgE

Associated with Mast cells. Causes mast cell release of histamine, prostaglandins, leukotrienes, producing symptoms of allergy. Real role is resistance to parasites.

29

Antibody Concentration in blood high to low

GAMDE

30

Type I hypersensitivity

Too much IgE causing mast cell degranulation. Can be asthma, allergic reaction to bee sting, allergic reaction.

31

Type II hypersensitivity

Autoimmunity due to antibodies which can react against self. Ex. hemolytic disease of newborn, myasthenia gravis.

32

Type III hypersensitivity

Occur when make antibody against soluble antigen. Commonly leads to arthritis, glomerulonephritis, pleurisy, rash. Also see serum sickness.

33

Type IV Hypersensitivity

Cell mediated hypersensitivty caused by CD4+ cells, can be autoimmune or bystander injury. Ex. reation with nickel, tuberculin reaction, chron's disease.

34

Cathelicidin LL37

alpha helical peptides which are bactericidal.

35

Defensins

Beta strand peptides connected by disulfide bonds. look like a fence. There are 2 classes. They all lead to excretion out of the cells and into membranes or viral envelopes dimerize and lead to holes in the membranes.

36

Cell response to TLR signaling

Activation of NF-kB and expression of pro-inflammatory genes.

37

INF gamma

leads to the activation of phagocytic cells and NK cells.

38

TNF alpha

produced by macrophages and other mononuclear phagocytes. Leads to induce fever, apoptotic cell death, cachexia, inflammation

39

Antibody typing

dependant on what the heavy chain is. Can be GAMED, but still reacts with the same things.

40

Light chain

contains the FAB region for antigen/ epitope recognition. Can either be a kappa or lambda type. One cell always produces the same light chain.

41

Antibody Isotype

Slight differences in the amino acid secuences of their H chain C regions, the 5 main classes of immunoglobulins.

42

IgG isotypes

IgG1 IgG2 IgG3 IgG4

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IgA Isotypes

IgA1, IgA2

44

IgM Isotypes

IgM1, Igm2

45

IgD Isotypes

Igd

46

IgE Isotypes

IgE

47

RAG recombinases

are the enzymes which do the recombination of antibody and T cell receptor DNA.