Viruses of the hematopoietic system Flashcards Preview

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Flashcards in Viruses of the hematopoietic system Deck (23):
1

Colorodo Tick Fever Virus Envelope and Genome

No, and dsRNA

2

Colorodo Tick Fever Virus Tropism

proerythrocytes and mature RBCs

3

Colorodo Tick Fever Virus Pathologies and tx.

Sadleback fever pattern, tick resevoir Supportive,

4

Cytomegalovirus Family and Genome

Herpes HHV-5 and dsDNA

5

Cytomegalovirus Tropism

Systemic, latent in CD34+ cells (monocyte to macrophages)

6

Cytomegalovirus pathology and Tx.

CMV infectious mononucleosis. Owl's eyes cells, congenital systemic CMV, deafness. Supportice care and gancicolivir for immunocompromised patients.

7

HHV-6 and HHV-7 Genome and envelope

dsDNA, envelope present (as in all HHV)

8

HHV-6 and HHV-7 Tropism

CD4+ Tcells, epithelial cells and others

9

HHV-6 and HHV-7 Pathologies and Tx.

Exanthem subitum (roseola), rash that develops after fever resolves. supportive tx and ganciclovir and cidofovir in imunocompromoised patients

10

Epstein Barr Virus (HHV-4) Genome and envelope

dsDNA, envelope present (as in all HHV)

11

Epstein Barr Virus (HHV-4) Tropism

Acute: epithelial cells of oropharynx
Latent: B cells

12

Epstein Barr Virus (HHV-4) Pathologies and Tx.

EBV infectious Mono, Burkitt Lymphoma, Hodgkin and nonhodgkin lymphoma. x-linked lymphoproliferative disease: inherited mutation in SAP adapter. Tx. supportive for mono

13

Kaposi Sarcoma herpes virus (HHV-8) Tropism

Epithelial cells, B cells

14

Kaposi Sarcoma herpes virus (HHV-8) Pathologies and tx.

Is present in immunocompromised pts. only. kaposi sarcoma, primary effusion lymphoma, multifocal castleman's disease. Tx. Ganciclovir, cidofir, foscarnet

15

Parvovirus B19 Genome and Envelope

ssDNA, no envelope

16

Parvovirus B19 Tropism

Erythroid Progenitor cells

17

Parvovirus B19 Pathologies and Tx.

Slapped cheek syndrome, transient aplastic crisis in patients with underlying anemia. Tx. Supportive

18

Human T Lymphotrophi Virus-1 Family, Genome, Envelope

Retroviridae, ssRNA, Yes

19

Human T Lymphotrophi Virus-1 Tropism

T cells

20

Human T Lymphotrophi Virus-1 Pathologies and tx.

Acute lymphoma/ leukemia, viral transcription factor Tax drives proliferation, blocks apoptosis. Inflammation on the spine. Tx. (chemotherapy/ bone marrow transplant)

21

HIV-1 Family, Genome, Envelope

Retroviridae, ssRNA, enveloped

22

HIV-1 Tropism

CD4+ T-cells, CD4+ monocytes, macrophages and others

23

HIV-1 Pathologies and Treatments

AIDS, depletion of CD4 T cells allowing opportunistic infections. Tx. Multiple antiretroviral agents