Anti-inflammatory drugs Flashcards Preview

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Flashcards in Anti-inflammatory drugs Deck (29):
1

List the three main classes of anti-inflammatory drugs

salicylates, Non steroidal antiinflammatory drugs, corticosteroids

2

What is the mechanism of action for salicylates (subclass of NSAIDS)?

inhibit synthesis of protaglandins

3

What is the mechanism of action for NSAIDS?

inhibit synthesis of protaglandins

4

What is the mechanism of action for corticosteroids?

block arachidonic acid, decrease production of prostiglandins and leukotrienes

5

What is the funtion of cyclooxygenase-1 (COX-1)?

reduces gastric-acid secretion, promotes renal blood flow, promotes platelet aggregation

6

What happens when COX-1 I inhibited?

bleeding, gastric upset, reduced renal funtion

7

What is the purpose of COX-2?

promotes inflammation, sensitizes pain receptors, mediates fever in brain

8

What happens when COX-2 is inhibited?

suppression of inflammation

9

____________ is found in ALL body tissues, while _________ is only present at sites of injury.

COX-1, COX-2

10

___________ are the newest and most controversial class of anti-inflammatory drugs

COX-2 inhibitors

11

T or F: COX-2 inhibitors also inhibit COX-1

FALSE: Cox-2 inhibitors inhibit COX-2 only

12

____________ are the treatment of choice for moderate to severe inflammation.

COX-2 inhibitors

13

What is the only remaining COX-2 inhibitor on the market?

celebrex

14

What is a well-known prototype in the salicylates class?

aspirin

15

Aspirin works by:

treating inflammation by inhibiting both COX-1 and COX-2 (inhibiting prostaglandin synthesis)

16

What are some adverse reactions to aspirin?

bleeding and GI irritation, renal and hepatic toxicity

17

What can occur in children and teenagers with acute febrile illness who are given aspirin ?

reye syndrome

18

T or F: acetaminophen (tylenol) is an NSAID.

FALSE!!! Has NO anti-inflammatory action!

19

What are the primary drugs given to treat mild to moderate inflammation?

NSAIDS

20

The NSAID class includes which 3 main drugs?

aspirin, ibuprofen, COX-2 inhibitors

21

Prednisone is an example of a______________ which is in the ____________ class.

corticosteroid, glucocoticoid

22

Prednisone decreases inflammation by:

decreasing formation, release, and activity of endogenous mediators of inflammation and modifying the body's immune response

23

What are some serious adverse effects of prednisone?

adrenal suppression, psychosis, hyperglycemia

24

T or F: Before administering a NSAID, baseline kidney and liver function tests as well as a CBC should be performed

TRUE

25

While a patient is on NSAIDS, a nurse should be assessing for 3 main things:

1. GI bleeding 2. Changes in pain as well as reduction in temperature and inflammation 3. assess for adverse side effects such as nephrotoxicity, hemolytic anemia, salicylate toxicity

26

What is the mechanism of action for antipyretic drugs?

reduce fever by direct action on the hypothalamic heat-regulating center

27

What is the prototype drug in the antipyretic class?

acetaminophen (tylenol)

28

What is the primary use of tylenol?

to relieve pain and reduce fever-NO ANTI INFLAMMATORY ACTIONS!

29

What is an adverse effect of tylenol?

possible liver damage