Cancer drugs Flashcards Preview

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Flashcards in Cancer drugs Deck (36):
1

This class of cancer drug is cell-cycle non-specific and substitutes and alkyl group for a hydrogen atom which results in interference of DNA replication and RNA transcription:

alkylating agents

1

An example of an alkylating agent is:

cisplatin

2

T or F: A patient taking cisplatin will liekly experience mucositis and esophagitis.

FALSE

3

Patients taking this drug commonly experience severe nausea and vomiting, as well as a metallic aftertaste in their mouths

cisplatin

4

Antitumor antibiotics mechanism of action is:

inhibiting cell division by binding to DNA and interfering with RNA transcription

5

An example of an antitumor antibiotic is:

doxorubicin

6

A person taking doxorubicin is not likely to experience:

renal or hepatic toxicity

7

Patients that complain of an abnormal dryness of the mouth (xerostomia) are most likely taking:

doxurubicin

8

Drugs that interfere with nucleic acid synthesis by substituting drug for purines or pyrimidines necessary for normal cellular function are:

Antimetabolites

9

A patient taking an antimetabolite drug who is having difficulty with vitamin B12, fat and D-xylose absorption, has renal and hepatic toxicity, and change in taste acuity is taking:

methotrexate

10

When a patient is taking __________________ they should avoid pyridoxine supplementation

fluorouracil

11

A patient taking an antimetabolite drug and is experiencing moderate vomiting, anorexia, severe mucositis and esophagitis, diarrhea, and hepatic toxicity. Clinical tests reveal no sign of renal toxicity. The drug is:

fluorouracil

12

Hormones/hormone modifier drugs work by:

altering cellular metabolism by changing body hormonal milieu for unfavorable tumor growth

13

List one hormone used for treating cancer:

glucocorticoids

14

A person taking glucocorticoids may experience mild nausea and vomiting T or F:

TRUE

15

hyperpagia, sodium and fluid retention, gastrointestinal upset, glucose intolerance, K+ wasting, osteoporosis, and negative nitrogen balance are all sides effects of:

glucocorticoids

16

This class of cancer drug works by inhibiting mitotic spindle formation and blocking mitosis:

Plant alkaloids

17

Liat an example of a plant alkaloid drug:

vincristine

18

A person experiencing mild vomiting, anorexia, mucositis and esophagitis, alternating constipation and diarrhea, and hepatic toxicity is taking:

vincristine

19

What is one hallmark side effect of vincristine?

hyponatremia (abnormally low level of sodium in the blood)

20

Interferon is a biologic response modifier that works by:

modifying host biologic responses to tumor

21

A noticible weight change (increase or decrease)can be associated with which drug?

interferon

22

A person taking interferon is NOT likely to experience:

mucositis & esophagitis and renal toxicity

23

T or F: A patient taking interferon will most likely experience severe vomiting.

FALSE

24

Renal tubular necrosis is associated with taking:

cisplatin

25

Methotexate can have what effect on the liver?

It can cause hepatic fibrosis

26

Fluid retention is a common side effect for:

glucocorticoids

27

Both alkylating agents and antitumor antibiotics interfere with DNA and RNA transcription. What is the difference between the two?

alkylating agents work by substituting an alkyl group for a hydrogen atom which interfers with DNA replication, while antitumor antibiotics bind to DNA and inhibit cell division

28

A side effect of Cisplatin may be the decrease of which 3 minerals?

Serum magnesium, potassium, and zinc

29

What are the most common indications for use for cisplatin?

Metastatic testicular, metastatic ovarian, and advanced bladder cancer

30

What are the most common indications for use for doxorubicin?

ALL and AML leukemias, solid tumors

31

What are the most common indications for use for methotrexate?

chemotherapy, trophoblastic tumors

32

What are the most common indications for use for fluorouracil?

colorectal and breast cancers

33

What are the most common indications for use for glucocorticoid steroids?

lymphomas and leukemias

34

What are the most common indications for use for vincristine?

ALL leukemia, hodgkin lymphoma, non-hodgkin lymphoma, solid tumors

35

What are the most common indications for use for interferon?

condyloma, leukemia, sarcoma, melanoma, lymphoma