Antiarrhythmics Flashcards Preview

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Flashcards in Antiarrhythmics Deck (21):
1

Class IA antiarrhythmics

Disopyramide "Double" --> heart failure
Quinidine "Quarter" --> tinnitus and tornado de points
Procainamide "Pounder" --> SLE-like syndrome
can also cause thrombocytopenia

2

Class IA MOA

inc AP duration
inc ERP
inc QT interval

3

Class IA uses

atrial and vent arrhythmias
re-entrant and ectopic SVT and VT

4

Class IB antiarrhythmics

Lidocaine "Lettuce"
Mexiletine "Mayo"
Tocainide "Tomato"
cause CNS stim/depression
CV depression

5

Class IB MoA

dec AP duration
prefers ischemic or depolarized Purkinje and vent tissue

6

Class IB uses

acute vent arrhythmias --> best post MI
digitalis-induced arrhythmias

7

Class IC antiarrhythmics

Moricizine "More"
Flecainide "Fries"
Propafenone "Please"
very pro-arrhythmic
contraindicated post mi

8

Class IC MoA

prolongs refractory period in AV node
has a minimal affect on AP duration

9

Class IC uses

SVT --> including A-fib
used as a last resort in refractory VT

10

Class II antiarrhythmic

Beta blockers
dec SA and AV nodal activity
dec cAMP and Ca++ currents
dec slope of phase 4
AV sensitive --> inc PR interval

11

Class II uses

SVT
slowing vent rate during atrial fib and flutter

12

Class II toxicity

impotence / exacerbation of COPD and asthma
may mask signs of hypoglycemia
CI in cocaine users
treat overdose with glucagon

13

Class III antiarrhythmics

K+ channel blockers "AIDS"
Amiodarone --> Class I, II, III, and IV effects; alters lipid profile
Ibutilide
Dofetilide
Sotalol

14

Class III MoA

inc AP duration
inc ERP
inc QT interval

15

Class III uses

a-fib and flutter
ventricular tachy (amiodarone and sotalol)

16

Class III toxicity

Sotalol and Ibutilide --> torsade
Amiodarone --> a lot including pul fibrosis and hyper/hypo thyroidism
check PFTs, LFTs and TFTs before starting this drug

17

Class IV antiarrhythmics

Ca++ channel blockers
Verapamil
Diltiazem

18

Class IV MoA

dec conduction velocity
inc ERP
inc PR interval

19

Class IV uses

prevention of nodal arrhythmias
rate control of a-fib
can cause flushing, edema, CV effects

20

Adenosine

inc K+ out of cells
hyper polarize cells and dec intracellular Ca++
used in supraventricular tacky
short acting
flushing, hypotn, chest pain
effects blocked by theophylline and caffeine

21

Mg++

effective in torsades and digoxin toxicity