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Flashcards in Endocrine Deck (32):
1

Propylthiouracil

inhib thyroid peroxidase and 5'-deiodinase

2

Methimazole

inhibits thyroid peroxidase

3

bromocriptine

Dopamine agonist
Tx for prolactinoma

4

Cabergoline

Dopamine agonist
Tx for prolactinoma

5

octreotide

somatostatin analog
Tx for acromegaly

6

pegvisomant

GH receptor antagonist
Tx for acromegaly

7

Demeclocycline

ADH antagonist
can cause secondary DI
can be used to Tx SIADH

8

Conivaptan

used to Tx SIADH

9

Tolvaptan

used to Tx SIADH

10

Lispro

rapid-acting insulin analog
bind insulin tyrosine kinase receptor
inc glucose stored as glycogen in liver
inc glycogen, protein synthesis, and K+ uptake in muscle
inc TG storage in fat
used to Tx DM1, DM2, GDM
SE: hypoglycemia

11

Aspart

rapid-acting insulin analog
bind insulin tyrosine kinase receptor
inc glucose stored as glycogen in liver
inc glycogen, protein synthesis, and K+ uptake in muscle
inc TG storage in fat
used to Tx DM1, DM2, GDM
SE: hypoglycemia

12

Glulisine

rapid-acting insulin analog
bind insulin tyrosine kinase receptor
inc glucose stored as glycogen in liver
inc glycogen, protein synthesis, and K+ uptake in muscle
inc TG storage in fat
used to Tx DM1, DM2, GDM
SE: hypoglycemia

13

IV insulin

short-acting insulin
used to treat DM1, DM2, GDM, DKA
also used to Tx hyperK+ (+glucose) and stress hyperglycemia

14

NPH

interm acting insulin
used to Tx DM1, DM2, GDM

15

Glargine

Long acting insulin
used to Tx DM1, DM2, GDM (basal glucose control)

16

Detemir

Long acting insulin
used to Tx DM1, DM2, GDM (basal glucose control)

17

Tolbutamide

first generation sulfonylurea
close K+ channels --> beta-cell depolarization --> Ca++ influx --> insulin release
stim release of endog insulin in DM2
req some islet f(x) so useless in DM1
SE: hypoglycemia
disulfram-like effects

18

Chlorpropamide

first generation sulfonylurea
close K+ channels --> beta-cell depolarization --> Ca++ influx --> insulin release
stim release of endog insulin in DM2
req some islet f(x) so useless in DM1
SE: hypoglycemia
disulfram-like effects

19

Glyburide

second generation sulfonylurea
close K+ channels --> beta-cell depolarization --> Ca++ influx --> insulin release
stim release of endog insulin in DM2
req some islet f(x) so useless in DM1
SE: hypoglycemia

20

Glimepiride

second generation sulfonylurea
close K+ channels --> beta-cell depolarization --> Ca++ influx --> insulin release
stim release of endog insulin in DM2
req some islet f(x) so useless in DM1
SE: hypoglycemia

21

Glipizide

second generation sulfonylurea
close K+ channels --> beta-cell depolarization --> Ca++ influx --> insulin release
stim release of endog insulin in DM2
req some islet f(x) so useless in DM1
SE: hypoglycemia

22

Pioglitazone

Thiazolidinedione
inc insulin sensitivity in periph tissues
binds PPAR-gamma nuclear xscrption regulator
stim secretion of adiponectin
use mono or in combo for DM2
SE: lb gain and edema
also can cause hepatotoxicity and heart failure

23

Rosiglitazone

Thiazolidinedione
inc insulin sensitivity in periph tissues
binds PPAR-gamma nuclear xscrption regulator
stim secretion of adiponectin
use mono or in combo for DM2
SE: lb gain and edema
also can cause hepatotoxicity and heart failure

24

Acarbose

alpha-glucosidase inhib
inhib enzyme in intestinal brush border
delayed sugar hydrolysis and glc absorption
dec postprandial hyperglycemia
mono or in combo for DM2
SE: GI disturbances

25

Miglitol

alpha-glucosidase inhib
inhib enzyme in intestinal brush border
delayed sugar hydrolysis and glc absorption
dec postprandial hyperglycemia
mono or in combo for DM2
SE: GI disturbances

26

Pramlinitide

amylin analog
dec gastric emptying
dec glucagon
used in DM1 and DM2
SE: hypoglycemia, nausea, diarrhea

27

Metformin

biguanide
dec gluconeogenesis
inc glycolysis
inc peripheral glc uptake (inc insulin sensitivity)
used in DM2
can be used in pt without islet f(x)
SE: GI upset
LACTIC ACIDOSIS --> CI in pt with renal failure

28

Exenatide

GLP-1 analog
inc insulin
dec glucagon release
used to Tx DM2
SE: nausea, vom, diarrhea

29

Liraglutide

GLP-1 analog
inc insulin
dec glucagon release
used to Tx DM2
SE: nausea, vom, diarrhea

30

Linagliptin

DPP-4 inhib
dec inactivation of GLP-1
used to Tx DM2
SE: mild urinary and resp inf

31

Saxagliptin

DPP-4 inhib
dec inactivation of GLP-1
used to Tx DM2
SE: mild urinary and resp inf

32

Sitagliptin

DPP-4 inhib
dec inactivation of GLP-1
used to Tx DM2
SE: mild urinary and resp inf