Nucleotide synthesis inhib Flashcards Preview

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Flashcards in Nucleotide synthesis inhib Deck (11):
1

Leflunomide

inhib dihydroorotate --> pyrimidine synthesis
inhib conversion of Carbamoyl phosphate to Orotic acid
cells arrested in G1
Cholestyramine can inc rate of elimination via interruption of enterohepatic circulation
Use as DMARD for RA
CI in prego

2

Mycophenolate

inhib IMP dehydrogenase --> purine synthesis
inhib conversion of IMP to GMP
used in xsplant immunosuppression

3

Ribavirin

inhib IMP dehydrogenase --> purine synthesis
inhib conversion of IMP to GMP
can be used as an antiviral; esp HCV

4

Hydroxyurea

inhib ribonucleotide reductase --> pyrimidine synthesis
inhib conversion of UDP to dUDP

5

6-mercaptopurine / azathioprine

inhib de novo purine synthesis --> purine synthesis
inhib conversion of PRPP to IMP
prodrug = azathioprine
metabolism inhibited by allopurinol = toxicity

6

5-FU

inhib thymidylate synthase --> pyrimidine synthesis
inhib conv of dUMP to dTMP

7

Methotrexate

inhib dihydrofolate reductase --> pyrimidine synthesis
inhib prod of dTMP due to inhibition of conversion of DHF to THF

8

Trimethoprim

inhib dihydrofolate reductase
inhib prod of dTMP due to inhibition of conversion of DHF to THF

9

Pyrimethamine

inhib dihydrofolate reductase
inhib prod of dTMP due to inhibition of conversion of DHF to THF

10

Allopurinol

hypoxanthine isomer
causes irrev inhib of xanthine oxidase --> inc plasma xanthine and hypoxanthine levels
Tx for Lesch-Nyhan Syndrome and gout

11

alpha-amantin

Amanita phalloides mushroom toxin
inhibits RNA Polymerase II
causes severe hepatotoxicity