Therapeutic Ab Flashcards Preview

Pharm > Therapeutic Ab > Flashcards

Flashcards in Therapeutic Ab Deck (13):
1

Alemtuzumab

targets CD52 (mature lymph)
used in CLL

2

Bevacizumab

targets VEGF
used in Colorectal cancer and renal cell Ca

3

Cetuximab

targets EGFR
stage IV colorectal cancer and head and neck cancer

4

Rituximab

targets CD20
used in B-cell non-Hodgkin lymphoma / RA (with MTX)/ ITP

5

Trastuzumab

targets HER2/neu
used in breast cancer and gastric cancer

6

Infliximab, Adalimumab

targets TNF-alpha
used in IBD / RA / AS / psoriasis

7

Natalizumab

targets alpha4-integrin --> leukocyte adhesion
used in MS / Crohn dz
there is a risk of PML in pt with JC virus

8

Abciximab

targets Glycoprotein IIb/IIIa
antiplatelet agent

9

Denosumab

targets RANKL
used in osteoporosis --> inhib osteoclast maturation (mimics osteoprotegrin)

10

Digoxin immune Fab

targets Digoxin
used as antidote for digoxin toxicity

11

Omalizumab

targets IgE
used for allergic asthma --> prevents IgE binding to FceRI

12

Palivizumab

targets RSV F protein
used for RSV prophylaxis for high risk infants

13

Vemurafenib

BRAF kinase inhibitor
used to for BRAF V600E mutated melanoma patients