Therapeutic Ab

Question 1

Alemtuzumab

Answer 1

targets CD52 (mature lymph)
used in CLL

Question 2

Bevacizumab

Answer 2

targets VEGF

used in Colorectal cancer and renal cell Ca

Question 3

Cetuximab

Answer 3

targets EGFR

stage IV colorectal cancer and head and neck cancer

Question 4

Rituximab

Answer 4

targets CD20

used in B-cell non-Hodgkin lymphoma / RA (with MTX)/ ITP

Question 5

Trastuzumab

Answer 5

targets HER2/neu

used in breast cancer and gastric cancer

Question 6

Infliximab, Adalimumab

Answer 6

targets TNF-alpha

used in IBD / RA / AS / psoriasis

Question 7

Natalizumab

Answer 7

targets alpha4-integrin –> leukocyte adhesion
used in MS / Crohn dz
there is a risk of PML in pt with JC virus

Question 8

Abciximab

Answer 8

targets Glycoprotein IIb/IIIa

antiplatelet agent

Question 9

Denosumab

Answer 9

targets RANKL

used in osteoporosis –> inhib osteoclast maturation (mimics osteoprotegrin)

Question 10

Digoxin immune Fab

Answer 10

targets Digoxin

used as antidote for digoxin toxicity

Question 11

Omalizumab

Answer 11

targets IgE

used for allergic asthma –> prevents IgE binding to FceRI

Question 12

Palivizumab

Answer 12

targets RSV F protein

used for RSV prophylaxis for high risk infants

Question 13

Vemurafenib

Answer 13

BRAF kinase inhibitor

used to for BRAF V600E mutated melanoma patients