Heme/Onc Flashcards Preview

Pharm > Heme/Onc > Flashcards

Flashcards in Heme/Onc Deck (14):
1

Heparin

cofactor for antithrombin activation
dec thrombin and Xa
used for immediate anticoag; monitor PTT
safe for prego
treat overdose with protamine sulfate
can cause HIT (IgG mediated)

2

Argatroban

hirudin derivative
direct thrombin inhibitor
use instead of heparin in pt with HIT

3

Bivalirudin

hirudin derivative
direct thrombin inhibitor
use instead of heparin in pt with HIT

4

Warfarin

epoxide reductase inhibitor
affects extrinsic pathway --> inc PT
used for chronic anticoagulation
CI in prego
can cause skin/tissue necrosis
give vitamin K to reverse

5

Apixaban

factor Xa inhibitor
used for DVT and PE prophylaxis
also for a-fib anti stroke proph
may cause bleeding

6

Rivaroxaban

factor Xa inhibitor
used for DVT and PE prophylaxis
also for a-fib anti stroke proph
may cause bleeding

7

tPA

helps convert plasminogen to plasmin
inc PT and PTT
no change in platelet counts
use in "golden hour" post MI
CI in pt with active bleeding and severe HTN
treat toxicity with aminocaproic acid (fibrolysis inhibitor)

8

Clopidogrel

irrev block ADP receptors --> inhib platelet aggregation
GpIIb/IIIa inhibitor --> inhib fibrinogen binding
use in acute coronary syndrome
reduce chance of stroke recurrence
can cause neutrophenia

9

Toclipidine

irrev block ADP receptors --> inhib platelet aggregation
GpIIb/IIIa inhibitor --> inhib fibrinogen binding
use in acute coronary syndrome
reduce chance of stroke recurrence
can cause neutrophenia

10

Prasugrel

irrev block ADP receptors --> inhib platelet aggregation
GpIIb/IIIa inhibitor --> inhib fibrinogen binding
use in acute coronary syndrome
reduce chance of stroke recurrence
can cause neutrophenia

11

Ticagrelor

irrev block ADP receptors --> inhib platelet aggregation
GpIIb/IIIa inhibitor --> inhib fibrinogen binding
use in acute coronary syndrome
reduce chance of stroke recurrence
can cause neutrophenia

12

Cilostazole

PDE III inhib --> inc cAMP in platelets
inhib platelet aggregation
vasodilator
used for claudication, angina and stroke proph
N/H/facial flushing/hypoTN/abdominal pain

13

Dipyridamole

PDE III inhib --> inc cAMP in platelets
inhib platelet aggregation
vasodilator
used for claudication, angina and stroke proph
N/H/facial flushing/hypoTN/abdominal pain

14

Abciximab

binds GpIIb/IIIa on ACTIVATED platelets --> inhib aggregation
made from monoclonal Fab fragments
used for unstable angina and percutaneous xsluminal coronal angioplasty
can cause bleeding and thrombocytopenia