which are beta lactamase resistance
very narrow spectrum:
Cefepime–4th gen of cephalosproin
which group of agents are used for surgical prophylaxis
1st gen cephalosporin: Cefazolin, Cephalexin
most common adverse efefct for Carbapenem
GI: nausea, vomiting, diarrhea
what does Imipenem bind to, to prevent kidney inactivating it?
Which drug causes flushing, “red man syndrome”
Adverse effects for Aminoglycoside?
What will cause resistance to aminoglycoside
enzymes altering chemical structure of drug
which antibiotic agents are used as prophylaxis in HIV
which drugs has drug efflux resistance
macrolides, Tetracycline, Fluoroquinolone
which tetracycline is used as antimalarial prophylaxis
Adverse effect for tetracycline?
Nutrient interaction: bind to Ca–>calcify tissue
photosensitivity to UV rays
which drug cause RBC suppresion?
which protein synthesis inhibitor drug should be avoided for pregnancy and children
which antibiotic can cause Stevenjohnson syndrom
which drug suppresses bone marrow?
Which drug causes Gray baby syndrome
which drug targets anaerobic transbacteria
what does pyrimethamine +sulfadiazine combo therapy treat
toxoplasmosis for AIDS
which drug competes with PABA
which drug group disrupts winding DNA and separtion of DNA strand
which drug binds to divalent cations, and prevent absorption of nutrients?
Fluoroquinolone–too much Ca (for example) will inhibit absorption because body absorbs Ca instead of drug
which drug causes QT prolongation
what drug is a topical that usually is a combo with Bacitracin?
which antibiotic causes myopathy?
which agent requires Ca++ to form pores on the mebrane
Which agent “punches wholes “ through membrane
which drug is very useful for resistant bacteria?
what causes myelosuppression>
which drugs inhibit PBP
All Beta lactams: Penecillin, Cephalosporin, Monobactam(Aztreonam), Carapenem
which drug prevents elongation of peptidoglycan cell wal by binding to D-ALA D-ALA pentapeptide
which drug blocsk incorporation of AA and nucleic acid into cell wall
which drug blocks the synthesis of UDP-N actylmurmamic acid
what are the mechanism of resistance for beta lactam compounds
Expression of bta lactamase, alteration in PBP binding to drug, Alteration in porin function*
what are the mechanism of resistances for Sulfonamide
- less sensitive drug target
- increased synthesis of PABA
- Scavenge or use other source of folid acid
what are the mech of Resistance for Fluoroquinolone
Less sensitive drug target
Transport drug out of cell (drug efflux)
Mech of resistance for Chloramphenicol
expression of inactivating enzymse
which drugs have resistance of drug efflux
Macrolide, tetracycline, fluoroquinolone
which protein synthesis inhibitors bind to 30s subunit
which protein synthesis inhibitors bind to 50 subunit
Macrolide, clindamycin, chloramphenicol, Linezolid
which drug inhibits the initial step of translation
what are the DNA synthesis inhibitors
Anti-folate drugs (Sulfonamides, Trimethoprim, Metronidazole) , and DNA gyrase inhibitors (Fluoroquinolone)
DNA gyrase inhibitors MOA
dirsrupting winding of DNA and sepration of DNA strand during transcription and translation
prodrug–>reductase activate drug–>become free radical that disrup and damage DNA function
inhibitor of bacterial dihydrofolate reductase–>impair DNA synthesis
which drug tx gonorrhea
which drug tx anthrax
what drug inhibits topoisomerase II and IV