PFOR enzyme activates which drug? and what does that drug cause?
Metronidazole; disrupts protein and DNA function
What is the drug of choice for all parasites?
Metronidazole
which drug(s) are used for cyst form E histolytica
idoquinol and paromomycin
which drug can treat invade intestinal disease as well as extraintestinal amebiasis (ie liver/brain abscess)
Metronidazole
which drug eliminates trophozoite and cyst form of E histolytica from Lumen of the intestine
Idoquinol, paromomycin
which drug should not be used with children?
iodoquinol
what route is Trichomoniasis treated with, and with what drug?
Metronidazole: topical gel or vaginal suppository if oral therapy is not effective
Metronidazole effect on Amebiasis
kills trophozoite form ONLY
which drug has the “disulfiram effect”
metronidazole
how is severe amebiasis treated
iodoquinol/paromomycin + metronidazole
which drug inhibits protein synthesis in bacteria
Paromomycin
which drug causes head ache, dry mouth, metallic taste, vomiting, diarrhea
Metronidazole
which drug would you have to take the longest to treat Amebiasis
Idoquinolol ~20 days vs 7 days with the other drugs
which drug inhibits PFOR?
Nitazoxanide
which drug inhibits folate synthesis
pyrimethamine, sulfadiazine, trimethoprim, sulfamethoxazole
which drug treats diarrhea from cryptosporidosis Parvum
Nitazoxanide, paromomycin
which drug inhibits dihydropteroate synthase
sulfonamides
which drug inhibit DHFR @ low concentration
Diaminopyrmidine
what is the treatment of choice for toxoplasmosis
pyrimethamine-sulfadiazine
how do high doses vs low doses effect?
High doses tx active disease
low doses tx life long maintenance
what is the side effect for sulfonamides?
rash
which drug tx pneumocystis Jirovecci infection
TMP-SMX
what makes up malarone
atovaquone + Proguanil
what is the MOA of Proguanil?
inhibits DHFR
what parasites do Nitazoxanide target
cryptosporidium parvum and Giardia Lamblia
Toxoplasmosis cyst tx
NONE!! pyrimethamine-sulfadiazine does not tx dormant cyst
