antiparasitic Flashcards Preview

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Flashcards in antiparasitic Deck (26)
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1
Q

PFOR enzyme activates which drug? and what does that drug cause?

A

Metronidazole; disrupts protein and DNA function

2
Q

What is the drug of choice for all parasites?

A

Metronidazole

3
Q

which drug(s) are used for cyst form E histolytica

A

idoquinol and paromomycin

4
Q

which drug can treat invade intestinal disease as well as extraintestinal amebiasis (ie liver/brain abscess)

A

Metronidazole

5
Q

which drug eliminates trophozoite and cyst form of E histolytica from Lumen of the intestine

A

Idoquinol, paromomycin

6
Q

which drug should not be used with children?

A

iodoquinol

7
Q

what route is Trichomoniasis treated with, and with what drug?

A

Metronidazole: topical gel or vaginal suppository if oral therapy is not effective

8
Q

Metronidazole effect on Amebiasis

A

kills trophozoite form ONLY

9
Q

which drug has the “disulfiram effect”

A

metronidazole

10
Q

how is severe amebiasis treated

A

iodoquinol/paromomycin + metronidazole

11
Q

which drug inhibits protein synthesis in bacteria

A

Paromomycin

12
Q

which drug causes head ache, dry mouth, metallic taste, vomiting, diarrhea

A

Metronidazole

13
Q

which drug would you have to take the longest to treat Amebiasis

A

Idoquinolol ~20 days vs 7 days with the other drugs

14
Q

which drug inhibits PFOR?

A

Nitazoxanide

15
Q

which drug inhibits folate synthesis

A

pyrimethamine, sulfadiazine, trimethoprim, sulfamethoxazole

16
Q

which drug treats diarrhea from cryptosporidosis Parvum

A

Nitazoxanide, paromomycin

17
Q

which drug inhibits dihydropteroate synthase

A

sulfonamides

18
Q

which drug inhibit DHFR @ low concentration

A

Diaminopyrmidine

19
Q

what is the treatment of choice for toxoplasmosis

A

pyrimethamine-sulfadiazine

20
Q

how do high doses vs low doses effect?

A

High doses tx active disease

low doses tx life long maintenance

21
Q

what is the side effect for sulfonamides?

A

rash

22
Q

which drug tx pneumocystis Jirovecci infection

A

TMP-SMX

23
Q

what makes up malarone

A

atovaquone + Proguanil

24
Q

what is the MOA of Proguanil?

A

inhibits DHFR

25
Q

what parasites do Nitazoxanide target

A

cryptosporidium parvum and Giardia Lamblia

26
Q

Toxoplasmosis cyst tx

A

NONE!! pyrimethamine-sulfadiazine does not tx dormant cyst