antihelminthic Flashcards

(36 cards)

1
Q

which drug inhibits mitosis in the parasite

A

Benzimidazole agents

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2
Q

which drugs cause paralysis of parasite

A

Ivermectin, pyrantel pamoate, and praziquantel

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3
Q

what nematodes do Albendazole and Mebendazole? how is it treated?

A

whip worm, hookworm, ascariasis, pinworm: SINGLE HIGH DOSE of either

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4
Q

which drug should not be used during preganancy?

A

Benzimidazole

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5
Q

Which drug is the 2nd line drug for strongyloidiasis

A

Thiabendazole

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6
Q

what drug treats cutaneous larval migrans (hookworms) through what route

A

Thiabendazole topical treatment

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7
Q

which is the drug of choice for Strongyloidiasis

A

Ivermectin

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8
Q

What nematodes do Ivermectin target

A

Filarial worms, B Malayi, O Vovulus, W. Bancrofti, L.Ioa

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9
Q

which drug is widely used to tx pinworms

A

Pyrantel pamoate

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10
Q

which drug is the only drug to treat tape worm and flukes? and how is it administered?

A

Praziquantel

Fluke: 3 doses in a single day
tapeworm: single dose
Cysticercosis: two weeks

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11
Q

which drug has serious nephrotoxicity ?

A

Amphotericin B

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12
Q

What chelps Amphotericin B decrease toxcicity

A

binding to lipid in delivery vehicle

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13
Q

through what administration is fungal meningitis treated from amphotericin B

A

intrathecal

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14
Q

which drugs are used to tx local infections of oropharyngela and vaginal candidiasis?

A

nystatin, clotrimazole, and miconazole

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15
Q

which drug treats thrush

A

Oral Iozenges

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16
Q

what nematodes do Fluconazole treat?

A

Candidiasis, cryptococcosis, coccidiomycosis

17
Q

which drug is 2nd line agent for histoplasmosis, blastomycosis, sporotrichosis

18
Q

which drug has the the lowest level interaction w/ p450 of all azole–which means widest therapeutic index

19
Q

which drug is the treatment of choiced that replaced Amotericin B for Aspergillosis?

20
Q

which antifungal drug requires low gastric pH for adsorption

21
Q

which drug is the drugo choice for Blastomycosis?

22
Q

which drug has the broadest spectrum of all azoles

23
Q

what bugs do Posaconazole target

A

Aspergillus, agent of mucormycoses, Cryptococcus, dimorphic gungi, candida

24
Q

which drug inhibits DNA syntheis

25
Itraconazole is the drug of choice for which bugs?
Blastomycosis, coccidiomycosis, histoplasmosis, sporotrichosis, dermatophyte
26
what bug does flucytosine mainly target
cryptococcus infectsion, some candida
27
which drug has bone marrow suppression
Flucytosine
28
which drug can treat Cryptococcal Meningities
Flucytosine
29
which drug inhibit beta glucans in order to inhibit fungal cell wall?
Echinocandins
30
what limits Echinocandins effects?
high levels of beta glucans in cell wall
31
which drug is is used to primarily treat invasive infection caused by Candida and aspergillus
Echinocandins
32
which drug is 2nd line tx for dermatophyte infections
Griseofulvin
33
what drugs can treat tinea cruris "jock itch" or tineal corporis "ring worm"
Allylamines
34
which drug is 1st line tx for onychomycosis; and MOA
Terbafine--bound to kertain, provdinging prolonged resistance to fungal invasion
35
where is terbafine mainly concentrated
skin, hairs, nails
36
which antifungals can penetrate CNS
Fluconazole, Flucytosine