antihelminthic Flashcards
(36 cards)
which drug inhibits mitosis in the parasite
Benzimidazole agents
which drugs cause paralysis of parasite
Ivermectin, pyrantel pamoate, and praziquantel
what nematodes do Albendazole and Mebendazole? how is it treated?
whip worm, hookworm, ascariasis, pinworm: SINGLE HIGH DOSE of either
which drug should not be used during preganancy?
Benzimidazole
Which drug is the 2nd line drug for strongyloidiasis
Thiabendazole
what drug treats cutaneous larval migrans (hookworms) through what route
Thiabendazole topical treatment
which is the drug of choice for Strongyloidiasis
Ivermectin
What nematodes do Ivermectin target
Filarial worms, B Malayi, O Vovulus, W. Bancrofti, L.Ioa
which drug is widely used to tx pinworms
Pyrantel pamoate
which drug is the only drug to treat tape worm and flukes? and how is it administered?
Praziquantel
Fluke: 3 doses in a single day
tapeworm: single dose
Cysticercosis: two weeks
which drug has serious nephrotoxicity ?
Amphotericin B
What chelps Amphotericin B decrease toxcicity
binding to lipid in delivery vehicle
through what administration is fungal meningitis treated from amphotericin B
intrathecal
which drugs are used to tx local infections of oropharyngela and vaginal candidiasis?
nystatin, clotrimazole, and miconazole
which drug treats thrush
Oral Iozenges
what nematodes do Fluconazole treat?
Candidiasis, cryptococcosis, coccidiomycosis
which drug is 2nd line agent for histoplasmosis, blastomycosis, sporotrichosis
Fluconazole
which drug has the the lowest level interaction w/ p450 of all azole–which means widest therapeutic index
Fluconazole
which drug is the treatment of choiced that replaced Amotericin B for Aspergillosis?
voriconazole
which antifungal drug requires low gastric pH for adsorption
Itraconazole
which drug is the drugo choice for Blastomycosis?
ITraconacole
which drug has the broadest spectrum of all azoles
Posaconazole
what bugs do Posaconazole target
Aspergillus, agent of mucormycoses, Cryptococcus, dimorphic gungi, candida
which drug inhibits DNA syntheis
Flucytosine