antifungal Flashcards

(27 cards)

0
Q

which drug has infused related action adverse effects aka “shake and bake”

A

ampotericin B

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1
Q

which drugs binds to ergosterol and punches holes through the membrane

A

amphotericin B and nystatin

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2
Q

which antifungal has nephrotoxicity

A

amphotericin B

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3
Q

which drugs are most commonly used as topicals for oropharygeal and vaginal candidas

A

nystatin, miconazole, clotrimazole

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4
Q

which drug treats thrush? alternative drug?

A

nystatin; Lozenges

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5
Q

Azoles characteristics

A

non toxic, inhibition to p450, all broad, resistance: efflux pump, mutation in target enzyme, decrease ergosterol in cell membrane, MOA: inhibit ergosterol synthesis

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6
Q

the agents of choice for Fluconazole

A

candidiasis, cryptococcosis, coccidomycosis

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7
Q

which drug has lowest level of interaction of p450 aka widest therapeutic indez

A

flucanazole

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8
Q

2nd line agent for fluconazole

A

histoplasmosis, blastomycosis, sporotrichosis

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9
Q

tx of choice for aspergillosis

A

voriconazole

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10
Q

which drug requires low pH for abdsorption

A

itraconazole

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11
Q

drug of choice for itraconazole

A

blastomycosis, histoplasmosis, coccidiomycosis, sporptrichosis, onchomycosis

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12
Q

which drug has the broadest spectrum of all azoles? what does it typically target

A

posaconazole; aspergillus, agents of mucormycoses

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13
Q

which drug inhibits protein and nucleic acid synthesis (dna synthesis)

A

Flucytosine

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14
Q

which drug treat cryptococcal meningitis

A

flucytosine

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15
Q

which drug has bone marrow suppression adverse effect

16
Q

which drugh inhibits fungal cell wall synthesis

A

Echinocandins

17
Q

what does echinocandin mainly tx

A

candida and aspergillus

18
Q

what antifungal drugs can penetrate cns

A

fluconazole, flucytosine

19
Q

2nd line tx for dermatophyte infection

20
Q

which drugs inhibit ergosterol synthesis

A

azoles and terbinafine

21
Q

which drug is the 1st line drug for onychomycosis

22
Q

what drugs tx tinea cruris, tinea corpis

A

allylamine:terbafine, naftifine

23
Q

What does nystatin mostly target

24
What's the difference between fluconazole and itraconazole
Itraconazole has a broader spectrum than fluconazole but poorer pharmacology and therapeutic index
25
what is itraconazoles effect on rifampin? digoxin? cyclosporine?
decrease rifampin below therapeutic level, raise digoxin and cyclosprine levels
26
what limits Echinocandins effects
high levels of beta glucan in cell wall