which drug has infused related action adverse effects aka “shake and bake”
ampotericin B
which drugs binds to ergosterol and punches holes through the membrane
amphotericin B and nystatin
which antifungal has nephrotoxicity
amphotericin B
which drugs are most commonly used as topicals for oropharygeal and vaginal candidas
nystatin, miconazole, clotrimazole
which drug treats thrush? alternative drug?
nystatin; Lozenges
Azoles characteristics
non toxic, inhibition to p450, all broad, resistance: efflux pump, mutation in target enzyme, decrease ergosterol in cell membrane, MOA: inhibit ergosterol synthesis
the agents of choice for Fluconazole
candidiasis, cryptococcosis, coccidomycosis
which drug has lowest level of interaction of p450 aka widest therapeutic indez
flucanazole
2nd line agent for fluconazole
histoplasmosis, blastomycosis, sporotrichosis
tx of choice for aspergillosis
voriconazole
which drug requires low pH for abdsorption
itraconazole
drug of choice for itraconazole
blastomycosis, histoplasmosis, coccidiomycosis, sporptrichosis, onchomycosis
which drug has the broadest spectrum of all azoles? what does it typically target
posaconazole; aspergillus, agents of mucormycoses
which drug inhibits protein and nucleic acid synthesis (dna synthesis)
Flucytosine
which drug treat cryptococcal meningitis
flucytosine
which drug has bone marrow suppression adverse effect
flucytosine
which drugh inhibits fungal cell wall synthesis
Echinocandins
what does echinocandin mainly tx
candida and aspergillus
what antifungal drugs can penetrate cns
fluconazole, flucytosine
2nd line tx for dermatophyte infection
Griseofulvin
which drugs inhibit ergosterol synthesis
azoles and terbinafine
which drug is the 1st line drug for onychomycosis
Terbafine
what drugs tx tinea cruris, tinea corpis
allylamine:terbafine, naftifine
What does nystatin mostly target
Candida
What’s the difference between fluconazole and itraconazole
Itraconazole has a broader spectrum than fluconazole but poorer pharmacology and therapeutic index
what is itraconazoles effect on rifampin? digoxin? cyclosporine?
decrease rifampin below therapeutic level, raise digoxin and cyclosprine levels
what limits Echinocandins effects
high levels of beta glucan in cell wall
