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Flashcards in antifungal Deck (27)
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0
Q

which drug has infused related action adverse effects aka “shake and bake”

A

ampotericin B

1
Q

which drugs binds to ergosterol and punches holes through the membrane

A

amphotericin B and nystatin

2
Q

which antifungal has nephrotoxicity

A

amphotericin B

3
Q

which drugs are most commonly used as topicals for oropharygeal and vaginal candidas

A

nystatin, miconazole, clotrimazole

4
Q

which drug treats thrush? alternative drug?

A

nystatin; Lozenges

5
Q

Azoles characteristics

A

non toxic, inhibition to p450, all broad, resistance: efflux pump, mutation in target enzyme, decrease ergosterol in cell membrane, MOA: inhibit ergosterol synthesis

6
Q

the agents of choice for Fluconazole

A

candidiasis, cryptococcosis, coccidomycosis

7
Q

which drug has lowest level of interaction of p450 aka widest therapeutic indez

A

flucanazole

8
Q

2nd line agent for fluconazole

A

histoplasmosis, blastomycosis, sporotrichosis

9
Q

tx of choice for aspergillosis

A

voriconazole

10
Q

which drug requires low pH for abdsorption

A

itraconazole

11
Q

drug of choice for itraconazole

A

blastomycosis, histoplasmosis, coccidiomycosis, sporptrichosis, onchomycosis

12
Q

which drug has the broadest spectrum of all azoles? what does it typically target

A

posaconazole; aspergillus, agents of mucormycoses

13
Q

which drug inhibits protein and nucleic acid synthesis (dna synthesis)

A

Flucytosine

14
Q

which drug treat cryptococcal meningitis

A

flucytosine

15
Q

which drug has bone marrow suppression adverse effect

A

flucytosine

16
Q

which drugh inhibits fungal cell wall synthesis

A

Echinocandins

17
Q

what does echinocandin mainly tx

A

candida and aspergillus

18
Q

what antifungal drugs can penetrate cns

A

fluconazole, flucytosine

19
Q

2nd line tx for dermatophyte infection

A

Griseofulvin

20
Q

which drugs inhibit ergosterol synthesis

A

azoles and terbinafine

21
Q

which drug is the 1st line drug for onychomycosis

A

Terbafine

22
Q

what drugs tx tinea cruris, tinea corpis

A

allylamine:terbafine, naftifine

23
Q

What does nystatin mostly target

A

Candida

24
Q

What’s the difference between fluconazole and itraconazole

A

Itraconazole has a broader spectrum than fluconazole but poorer pharmacology and therapeutic index

25
Q

what is itraconazoles effect on rifampin? digoxin? cyclosporine?

A

decrease rifampin below therapeutic level, raise digoxin and cyclosprine levels

26
Q

what limits Echinocandins effects

A

high levels of beta glucan in cell wall