Antibacterials 1.1

Question 1

how many hospital infections are G- bacteria?

Answer 1

30%

Question 2

MRSA

Answer 2

methicillin resistant

Question 3

classification of antibiotics

Answer 3

bacteriostatic

bacteriocidal

Question 4

bacteriostatic

Answer 4

stops growth

Question 5

bacteriocidal

Answer 5

kills bac

Question 6

cell wall synth inhibitors

Answer 6

beta lactam- penicillin

Others- cephalosporins, carbapenems, monobactams.

Question 7

bata lactam

Answer 7

four member ring.

Question 8

PBPs

Answer 8

build new cell wall during division. b lactic bind PBPs and weaken cell wall resulting in death.

both G+ and some G-

Question 9

penicillin mechanism of action

Answer 9

know the different kinds of penicillin.

Question 10

adverse reactions

Answer 10

*hypersensitivity to penecilloic acid*
diarrhea
nephritis
neurotoxicity
hemolytic anemia.

Question 11

Naf

Answer 11

staph

Question 12

cephalosporins

Answer 12

divided into 4 generations
1st to 4th more G-, broad spec.

1st-PEcK
2nd-HENPEK
3rd- *very important, cefotaxime, ceftazidime, ceftriaxome. treat meningitis. Tri to TAX TAZ
4th- cefipime
5th- ceftaroline against pseudomonas and MRSA

Question 13

Carbapenems and Monobactam

Question 14

Beta lactamase inhibitors

Answer 14

clavulcanic acid, sulbactam, tazobactam.

Question 15

Vancomycin

Answer 15

when bugs are resistant to other drugs.

Question 16

daptomycin

Answer 16

when bugs are resistant to vancomycin

Question 17

red man syndrome

Answer 17

Vancomycin toxicity

Question 18

Aminoglycosides

Answer 18

inhibit 30S subunit of initiation complex and blocks translocation
wide range spectrum

Question 19

Tetracyclines

Answer 19

inhibit 30S subunit preventing attachment of ammoniacal-tRNA

Question 20

50s inhibitors

Answer 20

chloraphanicol, clindamycin, macrolides, linezolid, strptogramin

Question 21

Fluoroquinolones

Answer 21

Oxasins
Target DNA gyros
active against pseudomonas.

Question 22

metronidazole

Answer 22

forms free radicals that damage DNA

Get GAP on the Metro

Question 23

nitrofurantoin

Answer 23

intermediates damage DNA, ribosomes
urinary tract infections
hepatotoxicity

Question 24

sulfonamides

Answer 24

target dihydrofolic synthase

Question 25

TB / leprosy drugs

Answer 25

rifampin…

Question 26

MRSA

Answer 26

Vancomycin, etc. what are effective against it?

Question 27

Pseudomonas

Answer 27

9 drugs effective against it.