Immunolgy 1.5

Question 1

antigenic variation

Answer 1

pathogens are able to evade immune response by avoiding antibody.

Question 2

antibody

Answer 2

150 mw protein
H + L proteins
antigen binds N-terminus
Variable region in red

Question 3

IgG

Answer 3

70-75% in circulation

only one that can cross placenta.

Question 4

IgA

Answer 4

secretory, in milk.

Question 5

IgM

Answer 5

5 subunits.

activates complement.

Question 6

IgD

Answer 6

not found in serum, mainly regulatory.

regulated Bcell activation

Question 7

IgE

Answer 7

Parasitic responses, binds mast cells.

Question 8

heavy chain

Answer 8

specific to each isotype.

Question 9

Functions of antibody slide**

Question 10

multiple myeloma

Answer 10

cancer of plasma cells

Question 11

Ig domain

Answer 11

found in other immune molecules, not variable in sequence.

Question 12

hinge flexibility

Answer 12

allows for binding many epitopes

Question 13

contributions of antibody to host defense

Answer 13

neutralization, opsonization, complement activation.

Question 14

naive B cells

Answer 14

membrane Ig with binding sites, encounters antigen, stimulates antibody secretion.

Question 15

hypervariable regions

Answer 15

make up antigen binding site,

Question 16

Lymphocyte development

Answer 16

hematopoetic stem cell is driven by trans factors to commit to B and T cell development

Question 17

negative selection

Answer 17

when cells react to host epitopes

they, sadly, don’t make it.

Question 18

positive selection

Answer 18

in periphery

selection for cells who recognize antigen

Question 19

heavy chain rearragement

Answer 19

Dj rearrangement, V-DJ rearranging — VDJ rearranged.

Question 20

DNA rearrangement

Answer 20

activates silent promoters— transcription