Immunology 1.3 Flashcards
(30 cards)
TLR signaling
recognize PAMPS, specific.
they then recruit adapter proteins
recruit protein kinases
activate transcription
E-selectin
involved in inflammation, specific to endotelium
macrophage activation via LPS
recognized by LBP, MD2, CD14. deliver to TLR complex
TIR domain delivers to MyD88*
NFkB signaling
activates pro inflammatory genes and T cells
most important!!!
causes fever through cytokines.
TLR4 deficiency
more susceptible to G- bacterial infections
NK cells
turned off by inhibitory receptors.
Ig like receptors-
lectin-like receptors- bind carbs
activate macrophages!
MHC-1
almost all over. LHA is more specific to humans, better name.
when cell is infected, MIC-ligand receptor overrides positive signal and it kills the cell.
NKC can be activated with decrease of LHA
IFN-y
major interferon of NK cells
TNF
key mediator of inflammation, control infections.
Il-1
discovered as pyrogen, causes fever.
chemokines
responsible for tissue influx
recruit cells to specific sites
type 1 interferrons
alpha and beta. resistance to viral infection
type 2 interferrons
gamma- activate macrophages, major prod of NK cells and T cells.****
IL-10, TGF-b
control of inflamation
IL-15
proliferation of NK cells
gamma chain
lymphocyte development
if you lack this you can’t respond to any of these cytokines
IL-2
t cell development
IL 4 and IL 5
B-cell development, anti inflamatory
IL-6
Pro inflamatory just like GP130
induces acute-phase protein prod by hepatocytes
Janus kinase
two faced kinase. used for cytokine signaling
STAT
signal transducer and activator of transcription used for cytokine signaling.
CXCL8
chemotactic factor recruits neutrophils and basos to site of infection
TNF-a
useful at low doses, toxic at high dose
can cause septic shock
fever in brain, vascular collapse
IL-12
Activates NK cells.
