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Flashcards in Antibiotic Therapy Deck (84)
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Vancomycin is a "BLANK"

Glycopeptide

1

Mechanism of action of glycopeptides

Inhibition of bacterial cell wall synthesis. Work at an earlier stage than do beta-lactams.

2

Daptomycin is a "BLANK"

Lipopeptide

3

Mechanism of action of Lipopeptides

Disruption of cell wall.

- Calcium dependent
- Depolarizes cell membrane
- Disrupts RNA, DNA, protein synthesis --> cell death

4

In general, Glycopeptides/Lipopeptides are active against:

Gram +ve organisms, including beta-lactam resistant organisms (i.e. MRSA)

5

Are Glycopeptides/Lipopeptides bacteriostatic or bactericidal?

Bactericidal

6

This Glycopeptide is slowly cidal, and when given PO is not systemically absorbed

Vancomycin

7

Lung surfactant inactivates "BLANK"; therefore, this agent should not be used to treat pneumonia!

Daptomycin

8

Spectrum and indications for Vancomycin IV

Spectrum: Gram +ve (Enterococci, penicillin resistant Streptococci, MRSA, CNS

Indications: Bacteremia, pneumonia, endocarditis, bone/joint, SSTI, surgical prophylaxis

9

Spectrum and indications for Vancomycin PO

Spectrum: C. difficile

Indications: C. difficile infection

10

Spectrum and indications for Daptomycin IV

Spectrum: Gram +ve (Enterococci, penicillin-resistant Streptococci, MRSA, CNS, and VRE)

Indications: Bacteremia, endocarditis, bone/joint, SSTI

11

Gentamycin and Tobramycin are both "BLANKS"

Aminoglycosides

12

Mechanism of action for Aminoglycosides

Inhibit protein synthesis by binding the 30S ribosomal subunit

13

Are Aminoglycosides bacteriostatic or bactericidal?

Bactericidal

14

Aminoglycosides are renally excretable and may cause the following toxicities (2)

1. Nephrotoxicity
2. Ototoxicity

15

Gentamicin and beta-lactams act synergistically against what?

Enterococci

16

Spectrum and indications for Gentamicin IV

Spectrum: Gram -ve, Pseudomonas, synergy vs Streptococci and Enterococci with beta-lactam or vancomycin

Indications: Drug resistant UTI, combination therapy for Gram -ve sepsis, synergy for Gram +ve bacteremia and endocarditis

17

Spectrum and indications for Tobramycin IV

Spectrum: Gram -ve, Pseudomonas (better than gentamicin)

Indications: Drug resistant UTI, combo therapy for serious Pseudomonas infections

18

Azithromycin is a "BLANK"

Macrolide

19

Mechanism of action for Macrolides

Inhibit protein synthesis by binding the 23S rRNA in the 50S ribosomal subunit

20

Macrolides are active against intracellular organisms, true or false?

TRUE

21

Are Macrolides bacteriostatic or bactericidal?

Bacteriostatic

22

Does Azithromycin have a long or short half life?

LONG

23

Spectrum and indications for Azithromycin IV/PO

Spectrum: Mycoplasma, Chlamydophila, Legionella, M. catarrhalis, Chlamydia trachomatis, N. gonorrheae, MAC

Indications: Combo therapy for MAC Tx, MAC prophylaxis in HIV pt's, 2nd line for STI's, combo with beta-lactam for CAP

24

Why is Azithromycin the preferred macrolide over erythromycin and clarithromycin? (5)

1. Broader spectrum
2. Fewer drug interactions
3. Once daily dosing
4. Tolerability
5. IV option

25

Clindamycin is a "BLANK"

Lincosamide

26

What is the mechanism of action of Clindamycin?

Inhibits proteins synthesis by binding to the 50S ribosomal subunit

27

What is the bioavailability of Clindamycin?

Excellent

28

Is Clindamycin bacteriostatic or bactericidal?

Bacteriostatic

29

Clindamycin inhibits toxin production from what?

Group A Streptococcus