Flashcards in Antibiotic Therapy Deck (84)
Vancomycin is a "BLANK"
Mechanism of action of glycopeptides
Inhibition of bacterial cell wall synthesis. Work at an earlier stage than do beta-lactams.
Daptomycin is a "BLANK"
Mechanism of action of Lipopeptides
Disruption of cell wall.
- Calcium dependent
- Depolarizes cell membrane
- Disrupts RNA, DNA, protein synthesis --> cell death
In general, Glycopeptides/Lipopeptides are active against:
Gram +ve organisms, including beta-lactam resistant organisms (i.e. MRSA)
Are Glycopeptides/Lipopeptides bacteriostatic or bactericidal?
This Glycopeptide is slowly cidal, and when given PO is not systemically absorbed
Lung surfactant inactivates "BLANK"; therefore, this agent should not be used to treat pneumonia!
Spectrum and indications for Vancomycin IV
Spectrum: Gram +ve (Enterococci, penicillin resistant Streptococci, MRSA, CNS
Indications: Bacteremia, pneumonia, endocarditis, bone/joint, SSTI, surgical prophylaxis
Spectrum and indications for Vancomycin PO
Spectrum: C. difficile
Indications: C. difficile infection
Spectrum and indications for Daptomycin IV
Spectrum: Gram +ve (Enterococci, penicillin-resistant Streptococci, MRSA, CNS, and VRE)
Indications: Bacteremia, endocarditis, bone/joint, SSTI
Gentamycin and Tobramycin are both "BLANKS"
Mechanism of action for Aminoglycosides
Inhibit protein synthesis by binding the 30S ribosomal subunit
Are Aminoglycosides bacteriostatic or bactericidal?
Aminoglycosides are renally excretable and may cause the following toxicities (2)
Gentamicin and beta-lactams act synergistically against what?
Spectrum and indications for Gentamicin IV
Spectrum: Gram -ve, Pseudomonas, synergy vs Streptococci and Enterococci with beta-lactam or vancomycin
Indications: Drug resistant UTI, combination therapy for Gram -ve sepsis, synergy for Gram +ve bacteremia and endocarditis
Spectrum and indications for Tobramycin IV
Spectrum: Gram -ve, Pseudomonas (better than gentamicin)
Indications: Drug resistant UTI, combo therapy for serious Pseudomonas infections
Azithromycin is a "BLANK"
Mechanism of action for Macrolides
Inhibit protein synthesis by binding the 23S rRNA in the 50S ribosomal subunit
Macrolides are active against intracellular organisms, true or false?
Are Macrolides bacteriostatic or bactericidal?
Does Azithromycin have a long or short half life?
Spectrum and indications for Azithromycin IV/PO
Spectrum: Mycoplasma, Chlamydophila, Legionella, M. catarrhalis, Chlamydia trachomatis, N. gonorrheae, MAC
Indications: Combo therapy for MAC Tx, MAC prophylaxis in HIV pt's, 2nd line for STI's, combo with beta-lactam for CAP
Why is Azithromycin the preferred macrolide over erythromycin and clarithromycin? (5)
1. Broader spectrum
2. Fewer drug interactions
3. Once daily dosing
5. IV option
Clindamycin is a "BLANK"
What is the mechanism of action of Clindamycin?
Inhibits proteins synthesis by binding to the 50S ribosomal subunit
What is the bioavailability of Clindamycin?
Is Clindamycin bacteriostatic or bactericidal?