Difficult to culture/Nonculturable Bacteria Flashcards Preview

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Flashcards in Difficult to culture/Nonculturable Bacteria Deck (27)
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Helicobacter and Treponema are "BLANKS"

Spirochetes

1

Helicobacter are distinguished by: (2)

1. Gram -ve
2. Spiral

2

3 pathogenic features of H. pylori

1. Acid resistant
2. Resides in stomach
3. cagA gene (aids in forming ulcers)

3

3 features of Treponema

1. Spirochete
2. Tightly wound
3. Cannot gram stain

4

2 virulence factors of Treponema pallidum

1. Lack of proteins on outer membrane
2. Antigenic variation

5

Clinical significance of Treponema pallidum (4)

1. Primary symphilis (painless chancre)
2. 2ndry syphilis: myalgia, headache, fever, rash on palms
3. tertiary syphilis: neurosyphilis (paralysis, tabes dorsalis), cardiovascular syphilis (aortic lesions, heart failure)
4. Congenital syphilis (facial and tooth abnormalities)

6

The genus Mycobacterium are (BLANK-BLANK) bacilli

Acid-fast

7

4 features of Mycobacterium

1. Non-spore forming, non-motile
2. Special Ziehl-Neelson staining needed
3. Slow growing
4. Fastidious growth requirements

8

2 virulence factors of M. tuberculosis

1. Survives and multiplies in alveolar macrophages
2. Carried to lymphatics and can start other foci of infection

9

Clinical significance of M. tuberculosis (4)

1. Primary pulmonary disease
2. Reactivation disease
3. Disseminated disease
4. Global problem

10

Pathogenicity of Mycobacterium avium complex

Inhibits lysosome-phagosome fusion

11

Clinical significance of Mycobacterium avium complex (3)

1. Pulmonary disease
2. Disseminated infection in AIDS patients
3. Opportunistic infection in immunocompromised hosts

12

Can Mycoplasma spp be gram stained?

No

13

2 features of Mycoplasma spp.

1. No cell wall
2. Need special growth media

14

Genital mycoplasma (M. hominis, M. genitalium) are resistant to what class of antibiotics?

Beta-lactams

15

What disorder does Genital mycoplasma cause in males?

Non-gonococcal urethritis

16

Pathogenicity of Mycoplasma pneumoniae

Polyclonal T-cell and B-cell activators trigger formation of cold agglutinins (clump RBCs)

17

Clinical significance of Mycoplasma pneumoniae (3)

1. Atypical pneumonia
2. Dermatologic involvement
3. Cardiac and neurologic complications

18

Which genus(s) of bacteria are considered obligate intracellular pathogens?

1. Chlamydia
2. Rickettsia

19

2 features of Chlamydia/Chlamydophila

1. Non-culturable, needs living cells
2. Intracellular

20

Pathogenicity of Chlamydia trachomatis (2)

1. Complicated intracellular lifecycle
2. Inhibits phagosome-lysosome fusion

21

8 presentations of Chlamydia trachomatis

1. Urethritis
2. Epididymitis
3. Proctitis
4. Cervicitis
5. Pelvic Inflammatory Disease (PID)
6. Conjunctivitis
7. Infants: conjunctivitis, pneumonitis
8. Lymphogranuloma venereum

22

What is the vector of Chlamydiaphila psittaci?

Birds

23

Chlamydophila psittaci causes which disease?

Atypical pneumonia

24

3 features of Rickettsia

1. Small, gram -ve
2. Requires living cells for growth
3. Zoonotic infections caused by ticks/mites/fleas

25

What disease is caused by Rickettsia rickettsii?

Rocky Mountain Spotted Fever (fever and rash)

26

Pathogenicity of R. rickettsii (2)

1. Tick vector
2. Cell to cell spread