Antibiotics Flashcards Preview

D1S U1 Microbiology > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (13):
1

Inhibitor of DNA replication by binding to DNA, only active in anaerobic microbes

Metronidazole

2

Antibiotics that affect DNA gyrase

Nalidixic Acid
Quinolones

3

Antibiotic that inhibits RNA polymerase

Rifamycin

4

Penicillin disrupts cell wall synthesis by competing with ______ to be cleaved by enzyme

D-alanine

5

4 ways to achieve selective toxicity:

1. Unique cell wall in microbes
2. Unique enzymes in microbes
3. Unique metabolites
4. Unique ribosome structure

6

This enzyme inactives drugs like Penicillin

Beta-lactamase

7

Some bacteria develop ______ to pump antibiotics out of them (resistance to tetracycline)

Efflux pumps

8

Some bacteria will alter their _____ or _____ pathways to combat antibiotics

Enzyme

Metabolic

9

3 ways antibiotic resistance spreads:

1. Chromosome associated resistance
2. Plasmid mediated resistance
3. Rapid spread of resistance

10

5 Ways Antibiotics inhibit bacteria:

1. Inhibition of cell wall synthesis
2. Disruption of cell membrane function
3. Inhibition of protein synthesis
4. Inhibition of nuclei acid synthesis
5. Action as antimetabolites

11

Disrupts cell membrane, binds to phospholipids

Polymyxin B sulfate

12

Tetracycline inhibits _____ to block the ribosome cycle

Transfer RNAs

13

Para-aminobenzoic acid (PABA) is an ______

Antimetabolite