Flashcards in Chlamydia Deck (15):
Small, gram-negative pathogen. No peptidoglycan in cell walls. Obligate intracellular pathogen. "Energy parasite"
Leading cause of preventable blindness. Most common agents of sexually transmitted bacterial infections. Causes "walking" pneumonia.
Chlamydial Infection spread by:
Droplet/direct contact. Infects mucosal epithelial cells. Localized (eyes, lungs, genitalia). Fingers, flies, fomites, fornication.
Causes Genital tract infections in both men and women, but usually asymptomatic in females. Infected infants get conjunctivitis and pneumonia.
C. Trachomatis infections
Transit form of C. Trachomatis. Enters epithelial cells (disguised as nutrients/growth factors/hormones), modifies endocytic vesicle, changes into larger intracellular active organisms (RB).
Elementary body (EB)
Chlamydial disease. STD. Systemic, invasive infection apparent in lymph nodes that drain genital tract.
Most prevalent chlamydial pathogen in human population. Usually asymptomatic or acute respiratory response. Can be directly observed in patients with atherosclerotic heart lesions.
Chlamydophila Pneumoniae treatment:
Antimicrobials target metabolic active RB forms.
Small gram negative rods. Obligate intracellular bacteria. Zoonoses- infections transmitted from animals to humans. Capable of independent metabolism (not energy parasites)
Causes Rocky Mountain Spotted Fever. Reservoir in Ticks.
Once inside blood, Rickettsiae attaches to ____ cells. And gets extruded from cells through ____
Vascular Endothelial cells (small blood vessels)
Obligate intracellular bacteria, transmitted by Lone Star tick. Infects monocytes/macrophages.
Diagnosis of Rickettsioses:
Problematic (usually too late for antibiotics)
Smallest organisms capable of growth on cell-free media. Requires sterol. Lack cell wall. Found in mammals/birds