Flashcards in Staphylococcus Deck (14):
S. Aureus will test coagulase _____
Most common causative agent of disease
_____ is a key player in the extracellular matrix function of adhesion of S. aureus.
Toxic oxidative substances released by PMNs (WBCs) to kill bacteria. Also damages host tissue (inflammation)
ROS (reactive oxygen species)
Virulence factors of S. aureus:
1. Polysaccharide capsule- blocks phagocytosis
2. Protein A- blocks antibody function
3. Pore-forming toxins- pop PMNs and other cells leading to more damage and inflammation (Panton-Valentine Leukocidin)
Syndrome where exfoliating toxins cause layers of epidermis to separate. (Toxins: Proteases with high-specificity for desmosomal proteins)
SSSS (Staphylococcal Scalded Skin Syndrome)
TSST-1 is a ______ (causes an unregulated inflammatory response by activating high numbers of CD4 T cells)
In Staphylococcal food poisoning, toxin is pre-formed in contaminated, unrefrigerated food. It is not an ______, rather an _____.
Many strains of S. aureus secrete enterotoxins that are heat stable:
1. Enterotoxins A, B, C, D, E
2. Superantigens- cause intense peristalsis
____ antimicrobial agents are inhibitory substrates for PBPs (Penicillin Binding Proteins- make peptidoglycan crosslinks). These include Penicillins, Cephalosporins, Carbapenems, Monobactams.
MSSA (Susceptible) vs. MRSA: Since MRSA (Methicillin Resistant S. aureus) is resistant to Beta-lactam drug classes, ____ is frequently used to treat MRSA. It is a glycopeptide class antimicrobial drug.
Less than ___% of the population carry MRSA, but ___% of healthcare professionals carry it. Colonization sites include Nares, Axilla, and Groin.
1. Gram stain?
2. Oxygen dependence?
3. Can it be isolated? How?
1. Gram positive
2. Facultative Anaerobes
3. Yes. 42 valid species isolated by Catalase positive test and 7.5% NaCl growth