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Pharmacology 2100 > Antidepressants > Flashcards

Flashcards in Antidepressants Deck (35):
1

what is reactive depression

temporary reaction to real stimuli - grief

2

what is bipolar disorder

recurrent major depressive episodes with intervening manic, hypomanic, or mixed episodes

3

what is major depression

one or more major depressive episodes free of manic, mixed, or hypomanic episodes

4

what is the clinical criteria for major depression

at least 5 symptoms for extended period of time

5

emotional symptoms

cant experinces pleasure
loss of interest
pessimistic
anxiety

6

physical symptoms

chronic fatigue
insomnia
appetite disturbance

7

cognitive symtoms

poor concentration
slow thinking
poor short term memory
confusion

8

psychomotor symptoms

slow movements and speech
agitation

9

some non pharms for major depression

psychotherapy
ECT

10

what is the amine hypothesis

depression is related to reduced synaptic levels of NE and serotonin

11

how do antidepressants work

blocking normal neurotransmitter reuptake processes

12

what is the therapeutic lag

drugs increase NT levels right away but efficacy is delayed by weeks

13

how does phase 2 work

phase 1 causes agonist activity at the receptors that feedback inhibit to stop amine released causing reduced negative feedback levels and phase 2 increase

14

examples of tricyclic antidepressants

amitriptyline
imipramine

15

how do TCAs work

mixed NE and serotonin reuptake inhibitors

16

what is the cause of adverse effects of TCAs

blockage of cholinergic, histaminergic, alpha1 adrenergic receptors

17

adverse effects of TCAs

orthostatic hypotension
tremour
insomnia
weight gain
siezure
sexual disturbance

18

drug interactions of TCAs

cyp2D6 inhibitors
sedatives
sympathomimetics
antimuscarinics

19

examples of serotonin reuptake inhibitors

fluoxetine
paraoxetine
sertraline

20

how do ssris work

block serotonin reuptake more than NE

21

overdose with TCAs causes

fatal cardiac arrthymias

22

why are ssris more tolerated than tca

less cholinergic, histaminergic, and adrenergic blockade
higher therapeutic index
does cause platelet inhibition tho

23

drug interactions with ssris

CYP 2D6 inhibitors
TCAs
beta blockers
antipsychotics

24

advantages of ssris over tcas

equal efficacy with milder side effects
more favourable therapeutic index
smaller chance of addictive drug interactions

25

exampls of snris

venlafaxine

26

mechanism of snris

inhibit both serotonin and NE reuptake and weak dopamine reuptake inhibitors

27

how are snris different from tcas

no affinity for muscarinic, alppha 1 adrengergic, and histaminergic receptors

28

advantages of snris

milder side effect
useful for depression with neuropathic pain
fewer druginteraction
lower safety margin

29

how does mirtazapine work

blocks alpha2 adrenergic receptors thus increase NE release
blocks histamine receptors

30

adverse effects of mirtazapine

sedation
weight gain - major drawback
less sexual side effects tho

31

drug interactions for mortazapin

none known

32

advantages of mirtazapine

anxiolytic/sedative effect
minimal drug interations

33

what is the mechanism for supropion

largely unknown
mi;d stimulant

34

how are the side effects different in bupropion

seizures major concern
no sexual dysfunction,weight gain, or sedation

35

drug interactions of bupropion

meds that lower seizure threshold
ldopa