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Flashcards in lecture 3 stuff Deck (24):
1

what are the 3 excretion steps (renal)

glomerular filtration
tubular reabsorption
tubular secretion

2

what enzyme are most drugs metabolized by

CYP 3A4/5

3

what is the importance of induction

allows enzyme to change in response to foreign substance

4

what are the effects of induction

increased clearance
decreased half life
decreased response

5

what factors other than drugs can cause induction

environment
smoking increases metabolism
herbal and nutritional supplements

6

what does a drug that is an enzyme inducer do

drug increases amount of enzyme for metabolism

7

what does a drug that is and enzyme inhibitor do

drug blocks metabolism of another drug

8

what are the effects of an enzyme inhibitor

increased response
increase half life
immediate effects

9

what does aspirin and warfarin cause

hemmorage

10

what does erythromycin and seldane cause

fatal arythmia

11

what does 2 CNS depressants cause

respiratory depression

12

what does viagra and nitro cause

hypotension

13

what does ACE inhibitors and potassium sparing diuretics cause

hyperkalemia

14

if a drug is an inhibitor what are the PK effects

decreased clearance
increased half life

15

if a drug is an inhibitor what are the PD effects

increased response
increased duration

16

in what ways does the CYP gene family vary

expression level
enzyme activity
enzyme induction

17

what type of metabolizer are most drugs made for

extensive metabolizer

18

what are poor metabolizers more prone to

increased risk of toxicity

19

what are people who are ultraextensive metabolizers more prone to

reduced response

20

how many CYP2D6 alleles are there? how many copies can it have

43 alleles
1-5, or 13 copies

21

how does the copies of CYP2D6 alleles affect metabolism

more copies = more metabolism

22

what would happen if you had 0 copies of the CYP2D6 allelle?
1-3?
13

0 - no metabolism may be toxic
1-3 adequate response
13 rapid metabolism overdose?

23

what do you do to a drug dose if someone has impaired organ that functions in metabolism or excretion

adjust dose

24

what are 3 outcomes of drug metabolism

inactivity
toxicity
water solubility