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Pharmacology 2100 > Gout > Flashcards

Flashcards in Gout Deck (19):
1

what is gout caused by

accumulation of uric acid crystals in joints
acute joint inflammation

2

why is gout known as rich mans disease

associated with a large intake of purine susch as red meat and wine

3

uric acid production*

purine nucleotides - inosinic acid - hypoxanthine- xanthine- uric acid

4

what enzyme converts hypoxanthine to xanthine

xanthine oxidase

5

what enzyme converts xanthine to uric acid

xanthine oxidase

6

what are the drug therapys of gout

colchicine
allopurinol
probenecid
NSAIDS

7

colchicine moa

anti inflammatory agent
impairs pmn motility or chemotaxtis thus inflammatory response to crystals
deosnt treat underlying cause so propylactic therapy

8

allopurinol

xanthine oxidase inhibitor reduces urate formation but risk of hypoxanthine stones

9

NSAIDS

drug of choice for gouty arthritis

10

probenecid

uricosuric: inhibits reabsorption of uric acid
inhibits excretion of other acidic drugs

11

local anesthetic

interrupts pain impulses in a specific region of the bodt without loss of patient consciousness
reversible

12

surface anesthesia

application of local anesthetic to skin or mucous membranes to relieve itching, burning, pain

13

nerve block

anesthetic injected around nerve that leads to operative site

14

peridural anesthesia

injected into peridural space (one of the coverings of the spinal cord)

15

spinal anesthesia

injected into subarachnoid space of the spinal cord

16

types of local anesthesia

epidural- spine
infiltration- inject into area
nerve block
spinal
topical

17

order of effects of anesthsia

first autonomic activity
then pain and other sensory lost
motor last to be lost
wear off in reverse order

18

what is anesthesia used for

surgery
dental procedures
diagnostics
some pain

19

when are there bad side effects of anesthesia

enters the CNS
intravascular injection
excessive dose or rate of injection
slow metabolic breakdown
injection into a highly vascular tissue