Sympathetic Pharmacology Flashcards Preview

Pharmacology 2100 > Sympathetic Pharmacology > Flashcards

Flashcards in Sympathetic Pharmacology Deck (63):
1

what do the 1,3,5 muscarinic receptors result in

excitation

2

what do the 2,4 muscarinic receptor result in

inhibition

3

which adrenergic receptor dilates pupils

alpha 1

4

which adrenergic receptor inhibits salvation

beta

5

which adrenergic receptor increases the heart rate

beta 1

6

which adrenergic receptor relaxes the airways

beta 2

7

which adrenergic receptor inhibits activity of the stomach

beta 2

8

which adrenergic receptor stimulates release of glucose and inhibits gall bladder

beta 2

9

which adrenergic receptos inhibits activity of the intestine

beta 2

10

which adrenergic receptor relaxes the bladder

beta 2

11

which adrenergic receptor promotes ejaculation adn vaginal contraction

alpha 1

12

what do alpha 1 act on

eyes and external genitalia
vasoconstriction

13

what do beta 2 receptors act on

lungs

stomach
gallbladder
intestine
bladder

14

what do beta 1 receptors act on

heart

15

what does noepinephrine mainly stimulate

alpha 1 receptors in blood vessels

16

what does epinephrine have an affinity for

beta receptor in cardiac muscle

17

what is the sym effect on the pupillary opening

contracts radial muscle causing dilation, midriasis

18

what is the para effect on the pupillary opening

contracts the circular muscle causing contraction , miosis

19

what is the para effect on lens focusing

contraction of ciliary muscle allowing near vision

20

what is the para effect on glands

M3 muscarinic stimulation secretes water product

21

what is the sym effect on glands

beta causes protein secretion
alpha causes vasoconstriciton which decreases water

22

what is the sym effect on vascular smooth muscle

alpha contracts skin vessels
muscarinic relaxes skeletal muscle vessels

23

what is the para effect on the endothlial cells

release EDRF which relaxes vessels

24

describe the baroreceptor reflex

decrease in blood pressure detected by carotid sinus/aortic arch causes decrease in firing rate of afferents. cardiovascular center increases sym activity and decreases para causing an increase in heart rate and stroke volume

25

what happens to organs that have destroyed sym or para nerves

they increase response to external neurotransmitters and upregulate receptors in end organs

26

what does the alpha 1 receptor cause

vasoconstriction
pupil dilation
inibits uterine contraction in pregnancy
ejaculation
contraction of bladder neck and prostate

27

what does the alpha 2 receptor cause

inhibits neurotransmitter release in presynaptic junction
inhibit insulin release
cardiac vasoconstriciton

28

what does the beta 1 receptor do

increases heart rate, force of contraction and velocity of conduction in AV node

29

what does the beta 2 receptor do

bronchial dilation
relax uterine muscle
vasodilation
glucose release

30

what is an alpha 1 agonist

pseudophedrine

31

what is an alpha antagonist

prazosin

32

what is an alpha 2 agonist

clonidine

33

what is a beta 1 agonist

isoproterenol
dobutamine

34

what is a beta 1 antagonist

propanolol

35

what is a beta 2 agonist

isoproterenol
terbutaline

36

what is a beta 2 antagonist

propanolol

37

define sympathomimetic

adrenergic agonists- stimulate sym receptors

38

what is epinephrine used for

bronchospasm
anaphylactic shock
cardiac arrest
with anasthetic

39

what is noepinephrine used to treat

shock

40

what is pseudoephedrine used to treat

nasal congestion

41

what are some examples of brain targeted non selective sympathomimetics how do they work

cocaine
amphetamines
ritalin
MDMA-ecstacy block reuptake of neurotransmitters

42

what drugs are used to treat parkinsons

selegiline inhibits monoamine oxidase and levadopa is a dopamine precursor

43

what are 2 types of antidepressants and example

monoamine oxidase inhibitor - phenelzine
tricyclic - amytriptyline

44

what is the primary function of an alpha 1 agonist

vasoconstriction

45

side effects of alpha 1 peripheral activation

sweat
manic
anxiety
paranoria
increased speed and thinking
weight loss
hyperglycemia
impotence
hypertension

46

beta 2 agonists used for bronchial dilation that are short acting

albuterol -salbutamol and ventolin

47

what is the beta 2 agonist used for bronchial dilation long actin

salmeterol

48

which agonists are adrenergic antagonists

alpha 2 agonists

49

what do anti-adrenergic drugs do

inhibit or block the effects of sym nerve stimulation

50

an example of alpha 2 agonist and what does it do

clonidine
inhibits release of NE in CNS so lowers BP

51

two drugs that are alpha 1 antagonists to decrease blood pressure

prazosin and doxasin

52

drug that is an alpha 1 antagonist to treat prostatic hypertrophy and vasospastic problems

tamsulosin

53

explain how both activation and inhibition is used to treat congestive heart failure

activate receptor subtype beta1 on heart to increase cardiac output and inhibit receptor subtype alpha 1 on peripheral vessels to decrease peripheral resistance

54

what are side effects of blocking alpha 1 receptors

orthostatic hypertension(head rush) early on
vertigo
sexual dysfunction
reflec tachycardia
floppy iris syndrome

55

what is a first generation beta blocker

non selective- can be beta 1 or 2

56

what are second generation beta blockers

selective for beta 1

57

what are third generation beta blockers

partially selective with alpha 1 inhibition

58

whu shouldnt you use propranolol in patients with asthma

non selective so will block beta 2 receptors and cause bronchospasm

59

how does propanolol help with angina and myocardial infarction

reduced oxygen demands

60

what drug is used for glaocoma
and why

timolol because blocks beta receptors and causes decreased production of aqeous humor

61

what drugs are used to treat hypertension for people with asthma or diabetes

second generation beta blocker atenalol

62

what is a third generation beta blocker with higher affinity for beta 1 and two

carvedilol
so reduces HR and exacerbates asthma

63

what is a third generation beta blocker that has a higher affinity for alpha 1

labetalol
so reduces Bp without large effect on HR