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Flashcards in Antipsychotic drugs Deck (21):
1

what is schizophrenia

chronic psychosis with deterioration of functional capacity

2

positive symptoms of schiz

hallucinations
delusions
disorganized speech
abnormal precense

3

negative symptoms

avolition(no motivation)
algoia (poverty of speech)
anhedonia (inability to feel pleasure)
blunted effect
absence of normal characteristics

4

what is the mechanism of schiz

too much mesolimbic dopamine causes postive symptoms
low dopamine in the mesocortical pathway causes negative symptoms

5

what is the mesolimbic system

ventral tegmental area activates nucleus accumbens through dop2

6

what is the mesocortical system

ventral tegmental area activates prefrontal cortex through dop1

7

how do most antipsychotics work

block d2 dopamine receptors relieveing postive symptoms

8

what do atypical antipsychotics work on

inhibit dopamine 1 and 2 relieving both positive and negative symptoms

9

examples of typical antipsychotics

chlorpromazine
fluphenazine
haloperidol
thiothixene

10

what are the adverse effects caused by

receptor non selectivity
blockade of non-mesolimbic d2 dopaminergic pathways

11

what are the adverse effects caused by receptor non-selectivity

antimuscarinic
alpha1 adrenergic blockade
histamine blockade

12

what is the nirgrostriatal pathway

substantia nigra activates striatum through dop D2 to coordinate voluntary movement

13

how do antipsychotics effect the nigrostriatal pathway

block d2 causing extrapyramidal side effects

14

what are the extrapyramidal side effects

parkinsons
akathisia (motor restlessness)
acute dystonic reactions
tardive dyskinesia

15

what is the tuberoinfundibular pathway

hypothalamus inhibits pituitary prolactin secretion through D2

16

how do antipsychotics affect the tuberoinfundibular pathway

block d2 causing increase prolactin production

17

side effects of blocking the tuberoinfundibular pathway

women- lactation ammenorrhea infertility
men- lactation impotence decreased libido gynecomastia

18

advantages of atypical antipsychotics

reduced d2 affinity so less extrapyrimidal side effects
also blockes 5ht2 receptors which decreases negative symptoms

19

how do atypical treat the negative symptoms

inhibits serotonin receptor which inhibits D1 so increases the mesocortical dopamine

20

what are some drug interactions

other sedatives
metoclopramide
SSRI antidepressants
antimuscarinics

21

dominant adverse effects of atypical antipsychotics

weight gain
hyperglycemia