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MOHD4: Exam 5 > Antidepressants, Stimulants, Bipolar Drugs > Flashcards

Antidepressants, Stimulants, Bipolar Drugs Flashcards

(60 cards)

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1
Q 
What class:
Imipramine
Amoxapine
Nortiptyline
Amitriptyline
A

Tricyclic Antidepressants

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2
Q

Treat major depression, affect noradrenergic and serotonergic synapses

A

Tricyclic Antidepressants

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3
Q

Side effects d/t blockage of muscarininc, adrenergic, histamine receptors

A

Tricyclic Antidepressants

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4
Q

Therapeutic activity begins in >2 weeks

A

Tricyclic Antidepressants, SSRIs

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5
Q

10-40 hour half life

A

Tricyclic Antidepressants

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6
Q

Metabolized by hepatic enzymes

A

Tricyclic Antidepressants

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7
Q

Eliminated by kidneys

A

Tricyclic Antidepressants, SSRIs, SNRIs, MAOIs, lithium salts

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8
Q

Antimuscarinic Effects

A

Blurred vision, dry mouth, urinary retention, constipation, glaucoma/epilepsy aggravation

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9
Q

Side effects include antimuscarinic effects

A

Tricyclic Antidepressants

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10
Q

Side effects: antimuscarinic, hypotension, tachycardia, sedation, weight gain, sexual dysfunction, seizures, psychiatric

A

Tricyclic Antidepressants

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11
Q

Fluoxetine, Citalopram, Escitalopram, Sertraline

A

Selective Serotonin Reuptake Inhibitors

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12
Q

Most widely prescribed antidepressants

A

SSRIs

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13
Q

1-3 day half life

A

SSRIs

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14
Q

High first pass hepatic metabolism

A

SSRIs

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15
Q

Block several liver enzymes

A

SSRIs

drug interaction potential

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16
Q

Demethylated to norfluozetine (has a 30 day half-life)

A

Fluoxetine

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17
Q

Early onset side effects: Nausea, Anxiety, Insomnia

A

SSRIs

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18
Q

Late onset side effects: Anorexia, Sexual Dysfunction, Mania if BPD

A

SSRIs

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19
Q

Drug Interactions d/t hepatic enzymes CYP2D6, CPY1A2, CYP3A4

TCAs, haloperidol, antiarrhythmics, beta-aderenergic antagonists

A

SSRIs

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20
Q

Venlafaxine

Duloxetine

A

SNRIs

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21
Q

Inhibit reuptake of 5-HT, NE

A

SNRIs

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22
Q

Treat patients refractory to SSRIs

A

SNRIs

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23
Q

11-12 hour half life

A

SNRIs

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24
Q

High binding to plasma proteins

A

duloxetine, SSRIs, TCAs

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25
Metabolized by CYP1A2 and CYP2D6
duloxetine
26
Contraindicated if hepatic insufficiency
duloxetine
27
Side effects: Nausea, Anxiety, Sleep disturbance, Sexual dysfunction, BP/HR if high dose
SNRIs
28
Bupropion mechanism
inhibit dopamine reuptake
29
Useful for rapid-cycling BPD
Burpropion
30
Inhibit serotonin reuptake and blocks 5-HT2 receptors
Nefazodone
31
Increases NE/5-HT by blocking alpha2 receptors
Mirtazapine
32
Used in combo with TCAs
Atypical antidepressants bupropion, nefazodone, mirtazapine
33
Side effects include headache, nausea, tinnitus, insomnia, nervousness
Atypical antidepressants bupropion, nefazodone, mirtazapine
34
Irreversibly block monoamine oxidase
Phenelzine, Tranylcypromine, Selegiline
35
Third line drug for depression
MAOIs
36
Increase presynaptic concentration of monoamines
MAOIs
37
MAOIs therapeutic effect requires
2-4 weeks
38
Effects persist due to long-term irreversible blockage
MAOIs
39
MAO-A deaminates
NE, 5-HT, DA
40
Severe and unpredictable side effects (CNS + Cardiovascular)
MAOIs
41
MAOIs + SSRIs -->
Serotonin Syndrome
42
delirium, coma, hypertension, tachycardia, hyperthermia, hyperreflexia, tremor
Serotonin Syndrome
43
Contain tyramine
cheese, liver, chicken, beer, wine
44
Risk of Cheese effect
MAOIs (tyramine excess --> increase in catecholamines
45
headache, tachycardia, hypertension, seizure, stroke
Cheese effect
46
Decrease manic + depressive states in BPD
lithium salts
47
Combine with antidepressants, neuroleptics, antiepileptics
lithium salts
48
Several weeks for onset
lithium salts
49
Very low therapeutic index
lithium salts Effective dose: 0.6-1.4 Toxic dose: 1.6-2.0 mEq/L
50
Sub for Na+ --> undesirable
lithium salts
51
Block hydrolysis of inositol phosphate --> prevent formation of phosphatidylinositol
lithium salts
52
Inhibit 5-HT1A, 5-HT1B
lithium salts
53
20-24 hour half life
lithium salts
54
CNS, cardiovascular, thyroid, renal, teratogenic, drug interaction side effects
lithium salts
55
Drug interactions with thiazide diuretics, NSAIDs
lithium salts
56
psychomotor stimulant
dextroamphetamine, methamphetamine
57
prevent narcolepsy, ADHD
dextroamphetamine, methylphenidate
58
Increase DA/NE in the brain
Stimulants: dextroamphetamine, methylphenidate, methamphetamine
59
Euphoria, anxiety, vertigo, insomnia, confusion, paranoia, psychoses, suicidal/homicidal tendencies, arrhythmia, hypertension, nausea, diarrhea, addition
Stimulants side effects
60
Phenelzine Selegiline Tranylcypromine
MAOIs

MOHD4: Exam 5 (23 decks)

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