Metastatic Disease of Skeleton Flashcards Preview

MOHD4: Exam 5 > Metastatic Disease of Skeleton > Flashcards

Flashcards in Metastatic Disease of Skeleton Deck (17):
1

Released by tumors, upregulates RANKL expression by osteoblasts

PTH-related protein (PTHrP)

2

Common places for hematogenous spread

Lungs
Liver
Bone
Brain

3

RANKL action

receptor expressed by osteoclast precursor cells, stimulate differentation

4

Purpose of radiation in metastatic disease

Pain relief

5

What is the most common mechanism of metastatic spread?

Lymphatic spread

6

Key component of bone remodeling

Receptor activator of nuclear factors kB Ligand

7

These cells secrete RANK-ligand

Osteoblasts

8

Cancers that spread to bone

Breast
Lung
thyroid
Prostate
Kidney

9

Actions of Osteoclasts

-resorb bone
-release calcium
-release growth factors --> stimulate cancer growth

10

Side effects of zoledronic acid

Osteonecrosis of jaw, atypical femur fractures

11

High calcium d/t bone breakdown can lead to

Paraneoplastic syndrome
Diffuse destruction

12

Binds RANKL preventing osteoclast differentiation

Osteoprotegerin

13

Bisphosphonate drug

zoledronic acid Zometa

14

Purpose of chemotherapy in metastatic bone cancer

Palliative

15

Action of zoledronic acid

bind to bone, taken up by osteoclasts, induce apoptosis, prevent resorption

16

Tumor cells produce factors that stimulate osteoblasts to secrete

RANKL

17

Denosumab

Binds RANKL, similar to OPG, blocks osteoclast maturation