Biological Rhythms Flashcards Preview

MOHD4: Exam 5 > Biological Rhythms > Flashcards

Flashcards in Biological Rhythms Deck (28):
1

Zeitgebers

light, food, activity

2

Intrinsically photosensitive

retinal ganglion

3

Responsible for generating circadian rhythms

suprachiasmatic nucleus

4

Associated with AD PER2 mutations

Advanced sleep phase disorder

5

Process S

Homeostatic need for sleep

6

Process C

circadian drive for arousal

7

May be caused by ATP breakdown and adenosine signaling

Sleep deprivation

8

Autoimmune destruction of orexin neurons

Narcolepsy

9

excessive daytime sleepiness, cataplexy, hypnagogig hallucinations, sleep paralysis, disturbed nocturnal sleep

Narcolepsy

10

Cardinal feature is reduced need for sleep

Bipolar disorder

11

Intrameal process that leads to termination of food intake

Satiety

12

Satiation

Process that controls intermeal interval

13

Grams of food consumed/intermeal interval

Satiety ratio

14

Meal phase: smell, sight, appeal, flavor, texture

Cognitive sensory

15

Meal phase: oral metering (sensory contact), osmotic load, gastric stretch

Pre-absorptive

16

Meal phase: nutrient absorption, digestive efficiency, neuroendocrine (CCK, insulin, GLPI)

Post-absorptive

17

Functions of meals

- Modulate nutrient intake
- Social interaction
- Set circadian rhythms

18

Key hypothalamic player in feeding

Arcuate nucleus

19

Inhibits feeding via aMSH acting on MC4R --> suppress food intake

POMC

20

Common mutation in obesity

MC4R

21

Promotes feeding via blocking MC4 receptor, blocking aMSH action

AgRP (agouti-related peptide)

22

Release GABA to inhibit POMC neuron activity --> promote appetite

NPY

23

Produced in stomach, pancreas, excitatory to NPY

Ghrelin

24

Produced by adipose, excitatory to POMC, inhibitory to NPY

leptin

25

Produced by duodenum, excitatory to POMC

Cholecystokinin

26

Produced by pancreatic beta-cells, excitatory to POMC

Insulin

27

Modafinil can treat

Narcolepsy, Shift work disorder

28

Lisdexamfetamine can treat

Binge eating disorder