Antiepileptice

Question 1

Carbamazepina contraindic

Answer 1

Sarcina
IH
BAV

Question 2

Zonisamida mec act

Answer 2

Inh canale Na,Ca voltaj dep (nu se mai propaga descarcarile specifice de tip epileptic)

-ef modulator pe inhibitie neuronala data de GABA

Question 3

Zonisamida ef adv

Answer 3

Somnolenta
Tulb GI
Manif cut

Question 4

Lamotrigina mecan act

Answer 4

-bloc canale Na
-inh elib glutamat

Question 5

Lamotrigina ef adv

Answer 5

-artralgii
-tuob cut
-tulb GI

Question 6

Gabapentina r adv

Answer 6

-artralgii,mialgii
-tulb vedere
-leucopenie
-inf virale

Question 7

Tiagabina

Answer 7

-inh recaptare GABA

Question 8

Vigabatrina

Answer 8

-inh GABA transaminaza(scade metab GABA)

-de electie in spasm infantil
-ef adv-pierdere vedere bilat progresiv si permanent,tulb psihotice

Question 9

Acid valproic

Answer 9

-bloc canale Na,Ca,creste GABA
-electie in absente
-adjuvant in crize de tip mioclonic,grand mal

R adv
-dismenoree,ovar polich
-hemoragii
-surditate
-tremur
-anemie
-trombocitopenie
-hipoNa

Question 10

Sdr gastaut

Answer 10

-lamotrigina peste 2 ani
-rufinamida peste 4
-topiramat
-felbamat

Question 11

Topiramat

Answer 11

-creste GABA
-bloc canale Ca
-inh anhidraza carbonica

Question 12

Felbamat

Answer 12

-bloc canale ca,Na
-bloc recep GABA,NMDA

Question 13

Retigabina

Answer 13

-desch canale neuronale de K
-ef adv-decol gri albastruie a unghii,buze,piele

Question 14

Acetazolamida

Answer 14

-inh anhidraza carbonica
-ef adv pe term scurt-parestezii,poliurie,scade apetit
-ef adv pe term lung-acidoza metab,tulb hidroel

Question 15

Levetiracetam

Answer 15

-interact cu prot 2A de la niv vezicula sinaptica( influ Ca intraneuronal)
-monoter in epilepsia cu criza partiale nou dg
-adjuvant in epilepsie idiopat,epilpsie mioclonica juvenila