Antiischemice

Question 1

De ce nu funct vasodil pe boli ischemice periferice?

Answer 1

-pt ca dilata vasele deja dilatate in zona ischemica si se provoaca fenomenul de furt arterial
-pt ca pot scadea tensiunea si astfel scade si mai tare fluxul in zona afectata

Question 2

Pentoxifilina

Answer 2

-pe isch perif
-derivat xantinic(purinic)
-inh fosfodiesteraza cu cresterea intracel a cAMP si a ATP->mareste circ fara modif TA
-scade fibrinigen plasmatic
-antiagregant
-oral forme cu elib prelung/iv

Indicatii
-marire circ membre ,creier
-claudicatie intermitenta
-tulb circ ocular,ureche int

R adv
-dureri epig
-dureri la injectare

Contraindic
-hemoragie intracraniana,retiniana

Question 3

Cilostazol

Answer 3

-pe isch perif
-inh fosfodiesteraza
-creste cAMP intracel
-nu scade risc CV
-ef antiagregant
-scade TG,creste HDL-colesterol(hipolipemiant)
-vasodil in special femural
-se da pt claudicatie intermitenta

R adv
-diaree
-tahicardie
-hipotens

Question 4

Naftidrofuril

Answer 4

-pe isch perif
-inh 5HT2 -antagoniseaza serotonina(vasoconstr si proagregant)

Indicatii
-arteriopat obliteranta
-post AVC(deficit cognitiv)
-sdr Raynaud ca trat adjuvant

Question 5

Prostanoizi

Answer 5

-pe isch perif
-ef vasodil,fibrinolitic,antiagregant
-pt sdr Raynaud asociat sclerodermie-ILOPROST

Question 6

Tratament adjuvant in Boli arteriale perif

Answer 6

-antiagregant
-antiplachetar
-hipolipemiant
-pe langa antiischemic(se monit la 3-6 luni daca a disparut simptomat-e medic simptomatologic—daca nu s a oprit ,scoatem medicam)

Question 7

Vincamina

Answer 7

-alcaloid din frunze de vinca
-antiisch cerebral
-vasodil cerebral
-antiagregant
-creste oxigare glucoza

Question 8

Vinpocetina

Answer 8

-CAVINTON
-antiisch vasodil cerebral
-antiagregant
-ef nootrop(ameliorare metab neuronal)
-poate da hipotens si tahicard la doze mari
-nu merge pe AVC ISCH ACUT

Question 9

Extract de GINKGO-BILOBA

Answer 9

-TANAKAN
-vasodil antiisch cerebral
-creste circ in membre si creier
-activeaza metab celular anaerob
-merge pe probl cognitive varstnici(atentie memorie)

Question 10

Nimodipina

Answer 10

-BCC
-folosit ca antiisch vasodil cerebral
-hipotensor
-lipofil,efect protector neuronal
-antiagregant

Indicatii
-NU LA AVC ischemic
-pe hemoragia subarahnoidiana data de vasospasmul aparut post rupere anevrismala

Ef adv
-hipotens
-hepatotox
-bufeuri vasomotorii
-colici abd
-greata
-flebita la loc inj

Question 11

Deriv de ergot

Answer 11

-nicergolina(semion)
-dihidroergotoxina

-nu se mai util pt ef adv mari(fibroza,ergotism)