Flashcards in Antifungals Deck (22)
Causes accumulation of squalene that inhibits ergosterol synthesis?
Causes accumulation of lanosterol that inhibits ergosterol synthesis?
Tx for cryptococcal meningitis?
Amphotericin B + flucytosine
Given intrathecally for fungal meningitis?
Amphotericin B--bc it does not cross BBB
Wide-spectrum used for systemic mycoses?
Amphotericin B, itraconazole
May causes arrhythmias due to changes in K and Mg levels?
Too toxic for systemic use, only used for oral candidiasis, diaper rash and vaginal candidiasis?
Used for candiduria due to it being metabolized by kidneys?
Used for chronic suppression of cryptococcal meningitis in AIDS?
Fluconazole--bc i can cross BBB
Inhibits ergosterol synthesis by inhibiting P450?
Azoles used for topical fungal infections?
Clotrimazole and micronazole (too toxic for systemic use)
Inhibits testosterone synthesis causing gynecomastia?
Tx for Cushing's?
Converted to active form by cytosine deaminase?
May cause pancytopenia (bone marrow suppression)?
Inhibits synthesis of B-glucan?
Tx for invasive aspergillosis?
Use for fungal nail infections?
Drug may cause abnormal LFTs?
Disrupts mitosis in keratin-containing tissues?
Only anti-fungal that is teratogenic and carcinogenic?