Antifungals Flashcards Preview

Pharmacology > Antifungals > Flashcards

Flashcards in Antifungals Deck (22):
1

Causes accumulation of squalene that inhibits ergosterol synthesis?

Terbinafine

2

Causes accumulation of lanosterol that inhibits ergosterol synthesis?

Azoles

3

Tx for cryptococcal meningitis?

Amphotericin B + flucytosine

4

Given intrathecally for fungal meningitis?

Amphotericin B--bc it does not cross BBB

5

Wide-spectrum used for systemic mycoses?

Amphotericin B, itraconazole

6

May causes arrhythmias due to changes in K and Mg levels?

Amphotericin B

7

Too toxic for systemic use, only used for oral candidiasis, diaper rash and vaginal candidiasis?

Nystatin

8

Used for candiduria due to it being metabolized by kidneys?

Fluconazole

9

Used for chronic suppression of cryptococcal meningitis in AIDS?

Fluconazole--bc i can cross BBB

10

Inhibits ergosterol synthesis by inhibiting P450?

Azoles

11

Azoles used for topical fungal infections?

Clotrimazole and micronazole (too toxic for systemic use)

12

Inhibits testosterone synthesis causing gynecomastia?

Ketoconazole

13

Tx for Cushing's?

Ketoconazole

14

Converted to active form by cytosine deaminase?

Flucytosine

15

May cause pancytopenia (bone marrow suppression)?

Flucytosine

16

Inhibits synthesis of B-glucan?

Caspsofungin

17

Tx for invasive aspergillosis?

Caspofungin

18

Use for fungal nail infections?

Terbinafine

19

Drug may cause abnormal LFTs?

Terbinafine

20

Disrupts mitosis in keratin-containing tissues?

Griseofulvin

21

Only anti-fungal that is teratogenic and carcinogenic?

Griseofulvin

22

Induces CYP450?

Griseofulvin