Antibiotics Flashcards Preview

Pharmacology > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (50):
1

Inhibits formation of initiation complex, causing misreading of mRNA?

Aminoglycosides

2

Prevents attachment of aminoacyl-tRNA to acceptor site?

Tetracyclines

3

Inhibits peptidyl transferase (EZ responsible for incorporating new amino acid into growing peptide strand)?

Chloramphenicol

4

Blocks aminoacyl-tRNA complex translocation step?

Macrolides

5

Blocks initiation complex formation and inhibits aminoacyl-tRNA complex translocation step?

Clindamycin

6

PABA analogue, competitively inhibits dihydropteroate synthase?

SMX

7

Inhibits bacterial dihydrofolic acid reductase?

TMP

8

Cell wall synthesis inhibitor causing hemolytic anemia?

Penicillin

9

Clavulanic acid?

Inactivates B-lactamases--added to ampicillin, amoxicillin

10

B-lactamase resistant due to bulkier structure?

Nafcillin, oxacillin, dicloxacillin

11

Tazobactam?

Inactivates B-lactamases--added to ticarcillin

12

Monocyclic B-lactam ring?

Aztreonam

13

Used in pts allergic to penicillin or in pts who are renally insufficient?

Aztreonam

14

Causes seizures?

Imipenem

15

Inhibits renal dihydropeptidase I?

Cilastatin--added to impenem

16

AEs of cephalosporins?

HSR, disulfiram-like rxn, nephrotoxicity

17

AEs of aminoglycosides?

Nephro, oto, and teratogen

18

Require O2 for uptake?

Aminoglycosides

19

Endocarditis prophylaxis before dental procedures in pts with valvular heart dz?

Clindamycin

20

Causes C. diff colitis?

Clindamycin, ampicillin

21

Alternative tx for bacterial meningitis?

Chloramphenicol

22

Causes myelosuppression (anemia, aplastic anemia)?

Chloramphenicol

23

Cause of gray baby?

Lack of UDP-glucuronyl transferase in newborn liver

24

Diphtheria tx?

Macrolides

25

Tx for atypcial pneumonia?

Macrolides, doxycycline

26

Chlamydia tx?

Macrolides, doxycycline

27

Inhibits CYP450?

Erythromycin

28

Cholera tx?

Doxycycline

29

Lyme dz tx?

Doxycycline

30

RMSF tx?

Doxycycline

31

Inhibited by divalent cations?

Tetracyclines

32

SIADH tx?

Demeclocycline

33

Competitive antagonist at V2 receptors?

Demeclocycline

34

Pneumocystis pneumonia tx?

TMP-SMX

35

UTI tx?

TMP-SMX

36

Kernicterus in newborns?

TMP-SMX

37

Inhibits DNA topoisomerase II?

Fluoroquinolones

38

Tx for recurrent UTIs?

Nitrofurantoin

39

Binds D-ala D-ala terminus, inhibiting transglycosylase?

Vancomycin

40

Increases permeability of cell membrane to polar molecules?

Polymyxins

41

Metabolized by bacteria into reduced reactive compounds that cause cell death?

Metronidazole

42

C. diff colitis tx?

Metronidazole

43

Giardiasis tx?

Metronidazole

44

Inhibits bacterial DNA-dependent RNA polymerase?

Rifampin

45

Inhibits synthesis of mycolic acid?

Isoniazid

46

Prophylax against TB?

Isoniazid

47

Causes peripheral neuropathy, must give B6?

Isoniazid

48

Dapsone MOA?

PABA antagonist inhibiting folic acid synthesis

49

Inhibits arabinosyl transferase?

Ethambutol

50

M. leprae tx?

Dapsone, rifampin, clofazimine