Antibiotics

Question 1

Inhibits formation of initiation complex, causing misreading of mRNA?

Answer 1

Aminoglycosides

Question 2

Prevents attachment of aminoacyl-tRNA to acceptor site?

Answer 2

Tetracyclines

Question 3

Inhibits peptidyl transferase (EZ responsible for incorporating new amino acid into growing peptide strand)?

Answer 3

Chloramphenicol

Question 4

Blocks aminoacyl-tRNA complex translocation step?

Answer 4

Macrolides

Question 5

Blocks initiation complex formation and inhibits aminoacyl-tRNA complex translocation step?

Answer 5

Clindamycin

Question 6

PABA analogue, competitively inhibits dihydropteroate synthase?

Answer 6

SMX

Question 7

Inhibits bacterial dihydrofolic acid reductase?

Answer 7

TMP

Question 8

Cell wall synthesis inhibitor causing hemolytic anemia?

Answer 8

Penicillin

Question 9

Clavulanic acid?

Answer 9

Inactivates B-lactamases–added to ampicillin, amoxicillin

Question 10

B-lactamase resistant due to bulkier structure?

Answer 10

Nafcillin, oxacillin, dicloxacillin

Question 11

Tazobactam?

Answer 11

Inactivates B-lactamases–added to ticarcillin

Question 12

Monocyclic B-lactam ring?

Answer 12

Aztreonam

Question 13

Used in pts allergic to penicillin or in pts who are renally insufficient?

Answer 13

Aztreonam

Question 14

Causes seizures?

Answer 14

Imipenem

Question 15

Inhibits renal dihydropeptidase I?

Answer 15

Cilastatin–added to impenem

Question 16

AEs of cephalosporins?

Answer 16

HSR, disulfiram-like rxn, nephrotoxicity

Question 17

AEs of aminoglycosides?

Answer 17

Nephro, oto, and teratogen

Question 18

Require O2 for uptake?

Answer 18

Aminoglycosides

Question 19

Endocarditis prophylaxis before dental procedures in pts with valvular heart dz?

Answer 19

Clindamycin

Question 20

Causes C. diff colitis?

Answer 20

Clindamycin, ampicillin

Question 21

Alternative tx for bacterial meningitis?

Answer 21

Chloramphenicol

Question 22

Causes myelosuppression (anemia, aplastic anemia)?

Answer 22

Chloramphenicol

Question 23

Cause of gray baby?

Answer 23

Lack of UDP-glucuronyl transferase in newborn liver

Question 24

Diphtheria tx?

Answer 24

Macrolides

Question 25

Tx for atypcial pneumonia?

Answer 25

Macrolides, doxycycline

Question 26

Chlamydia tx?

Answer 26

Macrolides, doxycycline

Question 27

Inhibits CYP450?

Answer 27

Erythromycin

Question 28

Cholera tx?

Answer 28

Doxycycline

Question 29

Lyme dz tx?

Answer 29

Doxycycline

Question 30

RMSF tx?

Answer 30

Doxycycline

Question 31

Inhibited by divalent cations?

Answer 31

Tetracyclines

Question 32

SIADH tx?

Answer 32

Demeclocycline

Question 33

Competitive antagonist at V2 receptors?

Answer 33

Demeclocycline

Question 34

Pneumocystis pneumonia tx?

Answer 34

TMP-SMX

Question 35

UTI tx?

Answer 35

TMP-SMX

Question 36

Kernicterus in newborns?

Answer 36

TMP-SMX

Question 37

Inhibits DNA topoisomerase II?

Answer 37

Fluoroquinolones

Question 38

Tx for recurrent UTIs?

Answer 38

Nitrofurantoin

Question 39

Binds D-ala D-ala terminus, inhibiting transglycosylase?

Answer 39

Vancomycin

Question 40

Increases permeability of cell membrane to polar molecules?

Answer 40

Polymyxins

Question 41

Metabolized by bacteria into reduced reactive compounds that cause cell death?

Answer 41

Metronidazole

Question 42

C. diff colitis tx?

Answer 42

Metronidazole

Question 43

Giardiasis tx?

Answer 43

Metronidazole

Question 44

Inhibits bacterial DNA-dependent RNA polymerase?

Answer 44

Rifampin

Question 45

Inhibits synthesis of mycolic acid?

Answer 45

Isoniazid

Question 46

Prophylax against TB?

Answer 46

Isoniazid

Question 47

Causes peripheral neuropathy, must give B6?

Answer 47

Isoniazid

Question 48

Dapsone MOA?

Answer 48

PABA antagonist inhibiting folic acid synthesis

Question 49

Inhibits arabinosyl transferase?

Answer 49

Ethambutol

Question 50

M. leprae tx?

Answer 50

Dapsone, rifampin, clofazimine